FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

SCHUMACHER RICHARD T 		2. Issuer Name and Ticker or Trading Symbol

PRESSURE BIOSCIENCES INC [ PBIO ] 		5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__ X __ Director                      _____ 10% Owner
__ X __ Officer (give title below)      _____ Other (specify below)
President, CEO
(Last)          (First)          (Middle)

130 LAKE RIDGE DRIVE 		3. Date of Earliest Transaction (MM/DD/YYYY)

12/19/2018
(Street)

TAUNTON, MA 02780
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
6. Individual or Joint/Group Filing (Check Applicable Line)

_ X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price

Table II - Derivative Securities Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3) 		2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8) 		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4) 		8. Price of Derivative Security
(Instr. 5) 		9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Non-Qualified Stock Option   $3.40   12/19/2018   (1)   D         2500      (1) 7/18/2028   Common Stock   2500   $0   0   (3) D    
Non-Qualified Stock Option   $3.40   12/19/2018   (1)   A      2500         (2) 12/19/2028   Common Stock   2500   $0   2500   (4) D    
Non-Qualified Stock Option   $3.40   12/19/2018   (1)   D         500      (1) 7/18/2028   Common Stock   500   $0   0   (3) D    
Non-Qualified Stock Option   $3.40   12/19/2018   (1)   A      500         (2) 12/19/2028   Common Stock   500   $0   3000   (4) D    
Non-Qualified Stock Option   $3.40   12/19/2018   (1)   D         1000      (1) 7/18/2028   Common Stock   1000   $0   0   (3) D    
Non-Qualified Stock Option   $3.40   12/19/2018   (1)   A      1000         (2) 12/19/2028   Common Stock   1000   $0   4000   (4) D    
Non-Qualified Stock Option   $3.40   12/19/2018   (1)   D         2500      (1) 7/18/2028   Common Stock   2500   $0   0   (3) D    
Non-Qualified Stock Option   $3.40   12/19/2018   (1)   A      2500         (2) 12/19/2028   Common Stock   2500   $0   6500   (4) D    
Non-Qualified Stock Option   $3.40   12/19/2018   (1)   D         41667      (1) 7/18/2028   Common Stock   41667   $0   0   (3) D    
Non-Qualified Stock Option   $3.40   12/19/2018   (1)   A      41667         (2) 12/19/2028   Common Stock   41667   $0   48167   (4) D    
Non-Qualified Stock Option   $3.40   12/19/2018   (1)   D         25000      (1) 7/18/2028   Common Stock   25000   $0   0   (3) D    
Non-Qualified Stock Option   $3.40   12/19/2018   (1)   A      25000         (2) 12/19/2028   Common Stock   25000   $0   73167   (4) D    
Non-Qualified Stock Option   $3.40   12/19/2018   (1)   D         25000      (1) 7/18/2028   Common Stock   25000   $0   0   (3) D    
Non-Qualified Stock Option   $3.40   12/19/2018   (1)   A      25000         (2) 12/19/2028   Common Stock   25000   $0   98167   (4) D    

Explanation of Responses:
(1)  The reported transactions involved an amendment of an outstanding stock option, resulting in the deemed cancellation of the old stock option granted on July 18, 2018 and the grant of a replacement stock option dated December 19, 2018, which includes the same exercise price of $3.40 and a new expiration date of December 19, 2028.
(2)  Stock options vest 5/36th for the first month then 1/36th per month for the remaining months for a total of 36 months.
(3)  2015 Nonqualified Stock Option Plan.
(4)  2013 Equity Incentive Plan.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
SCHUMACHER RICHARD T
130 LAKE RIDGE DRIVE
TAUNTON, MA 02780 		X
President, CEO

Signatures
/s/ Richard T. Schumacher 12/21/2018
** Signature of Reporting Person Date


Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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