MGEN Miragen Therapeutics Inc

miRagen Therapeutics, Inc. (NASDAQ:MGEN), a clinical-stage biopharmaceutical company focused on the discovery and development of RNA-targeted therapies, announced today that it will be presenting preclinical data on two of its three clinical-stage programs at upcoming scientific conferences. New preclinical data on MRG-110 will be presented at the 2018 Wound Healing Society (WHS) Annual Meeting being held April 25-29, 2018 in Charlotte, NC. MRG-110 is currently in a Phase 1 clinical trial in collaboration with Servier.  

In addition, new preclinical data on MRG-201 investigating the anti-fibrotic effects of a microRNA-29 mimic in the eye will be presented at the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting. The Company plans to initiate a Phase 2 clinical trial for MRG-201 in cutaneous fibrosis in the second quarter of 2018. miRagen also plans to publicly present preclinical data about microRNA mimics of the miR-183/96/182 cluster and their potential impact on preventing retinal degeneration and preserving photoreceptor function. The meeting is being held April 29 - May 3, 2018 in Honolulu, HI.

2018 Wound Healing Society Annual Meeting

Oral and Poster Presentation DetailsTitle: Improved perfusion and wound healing in healthy pigs with MRG-110, an Inhibitor of microRNA-92A

• Oral session: Session K: Concurrent Oral Abstracts II
• Date: Friday, April 27, 2018, 2:45 p.m. – 2:55 p.m. ET
• Location: Room 203B, Charlotte Convention Center

• Poster session: WHS Poster Gala & Awards
• Poster number: P.IRD4
• Date: Friday, April 27, 2018, 7:15 p.m. – 8:45 p.m. ET
• Location: Hall C1, Charlotte Convention Center

MRG-110 is an inhibitor of microRNA-92, which has been shown in preclinical studies to be a regulator of new blood vessel creation. miRagen believes microRNA-92 inhibitors may accelerate and improve healing and thus decrease complications of wounds in a variety of settings.

For additional information, please visit the WHS Annual Meeting website: www.woundheal.org

2018 Association for Research in Vision and Ophthalmology Annual Meeting

Oral Presentation DetailsTitle: Restoring miRNAs of the miR-183/96/182 cluster results in target gene regulation and ameliorates symptoms of retinal degeneration in a mouse model of retinitis pigmentosa

• Oral session: Session 473: Signaling in retinal degeneration
• Date: Wednesday, May 2, 2018, 3:30 p.m. – 5:15 p.m. HST
• Location: Room 315, Hawaii Convention Center

microRNAs of the miR-183/96/182 cluster have been shown to play an important role in the establishment and maintenance of neurosensory cells, including photoreceptors and hair cells (cells associated with hearing). Genetic ablation of the cluster in mice recapitulates features of retinitis pigmentosa in humans, a disease characterized by gradual loss of photoreceptors, resulting in eventual blindness. miRagen has developed mimics corresponding to each of the microRNAs in that cluster and is evaluating how restoring microRNA function could be a therapeutic approach to delaying or even preventing photoreceptor loss.

Poster Presentation DetailsTitle: Inhibition of ocular fibrosis with a miR-29b mimic

• Poster session: Session 489: Retina, drugs
• Poster number: C0249
• Date: Wednesday, May 2, 2018, 3:30 p.m. – 5:15 p.m. HST
• Location: Exhibit Hall, Hawaii Convention Center

MRG-201 is designed to mimic the activity of microRNA-29 and decrease the expression of proteins that are involved in fibrous scar formation. miRagen believes the results from its Phase 1 clinical trial of MRG-201 in induced cutaneous fibrosis, which demonstrated the potential of the product candidate to reduce fibroplasia in humans, may provide support for the therapeutic approach in other pathological fibrotic conditions, including ocular fibrosis.

For additional information, please visit the ARVO Annual Meeting website: www.arvo.org

About miRagen Therapeutics, Inc.

miRagen Therapeutics, Inc. is a clinical-stage biopharmaceutical company discovering and developing proprietary RNA-targeted therapies with a specific focus on microRNAs and their role in diseases where there is a high unmet medical need. miRagen has three clinical stage product candidates, cobomarsen (MRG-106), MRG-201, and MRG-110. miRagen’s clinical product candidate for the treatment of certain cancers, cobomarsen, is an inhibitor of microRNA-155, which is found at abnormally high levels in malignant cells of several blood cancers, as well as certain cells involved in inflammation. miRagen’s clinical product candidate for the treatment of pathological fibrosis, MRG-201, is a replacement for microRNA-29, which is found at abnormally low levels in a number of pathological fibrotic conditions, including cutaneous, cardiac, renal, hepatic, pulmonary and ocular fibrosis, as well as systemic sclerosis. MRG-110, an inhibitor of microRNA-92, is being developed under a license and collaboration agreement with Servier for the treatment of heart failure and other ischemic disease. In addition to these programs, miRagen is developing a pipeline of preclinical product candidates. The goal of miRagen’s translational medicine strategy is to progress rapidly to first-in-human studies once it has established the pharmacokinetics, pharmacodynamic, safety and manufacturability of the product candidate in preclinical studies. For more information, please visit www.miragen.com.

For information on clinical trials please visit www.clinicaltrials.gov.

Note Regarding Forward-Looking Statements

This press release may contain forward-looking statements that involve substantial risks and uncertainties for purposes of the safe harbor provided by the Private Securities Litigation Reform Act of 1995. All statements contained in this press release other than statements of historical fact, including statements regarding miRagen’s strategy, future operations, future financial position, future revenue, projected expenses, prospects, plans and objectives of management or the expected features of or potential indications for miRagen’s product candidates are forward-looking statements. The words “believe,” “may,” “will,” “estimate,” “continue,” “anticipate,” “intend,” “plan,” “expect,” “predict,” “potential,” “opportunity,” “goals,” or “should,” and similar expressions are intended to identify forward-looking statements. Such statements are based on management’s current expectations and involve risks and uncertainties. Actual results and performance could differ materially from those projected in the forward-looking statements as a result of many factors, including, without limitation: that miRagen has incurred losses since its inception, and anticipates that it will continue to incur significant losses for the foreseeable future; future financing activities may cause miRagen to restrict its operations or require it to relinquish rights; miRagen may fail to demonstrate safety and efficacy of its product candidates; miRagen’s product candidates are unproven and may never lead to marketable products; miRagen’s product candidates are based on a relatively novel technology, which makes it difficult to predict the time and cost of development and of subsequently obtaining regulatory approval, if at all; miRagen’s product candidates may cause undesirable side effects or have other properties that could delay or prevent the regulatory approval; and the results of miRagen’s clinical trials to date are not sufficient to show safety and efficacy of miRagen’s product candidates and may not be indicative of future clinical trial results.

miRagen has based these forward-looking statements largely on its current expectations and projections about future events and trends. These forward-looking statements are subject to a number of risks, uncertainties and assumptions, including those described under the heading “Risk Factors” in miRagen’s Annual Report on Form 10-K and subsequent periodic reports filed with the Securities and Exchange Commission. Moreover, miRagen operates in a very competitive and rapidly changing environment. New risks emerge from time to time. It is not possible for its management to predict all risks, nor can it assess the impact of all factors on its business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in any forward-looking statements it may make. In light of these risks, uncertainties and assumptions, the future events and trends discussed in this press release may not occur and actual results could differ materially and adversely from those anticipated or implied in the forward-looking statements. miRagen undertakes no obligation to revise or publicly release the results of any revision to such forward-looking statements, except as required by law. Given these risks and uncertainties, readers are cautioned not to place undue reliance on such forward-looking statements. All forward-looking statements are qualified in their entirety by this cautionary statement.

Investor/Media Contact:                                                   Adam Levy                                                   Chief Business Officer                                                   (720) 407-4595                                                   alevy@miragen.com