Statement of Changes in Beneficial Ownership (4)

FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^* COATS LONNEL	2. Issuer Name and Ticker or Trading Symbol LEXICON PHARMACEUTICALS, INC. [ LXRX ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __ X __ Director _____ 10% Owner __ X __ Officer (give title below) _____ Other (specify below) President and CEO
(Last) (First) (Middle) 8800 TECHNOLOGY FOREST PLACE	3. Date of Earliest Transaction (MM/DD/YYYY) 9/15/2017
(Street) THE WOODLANDS, TX 77381 (City) (State) (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) _ X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Common Stock	9/15/2017		P		300	A	$12.4866	3285	D ⁽¹⁾
Common Stock	9/15/2017		P		300	A	$12.485	3585	D ⁽¹⁾
Common Stock	9/15/2017		P		3300	A	$12.52	6885	D ⁽¹⁾
Common Stock	9/15/2017		P		5200	A	$12.54	12085	D ⁽¹⁾
Common Stock	9/15/2017		P		3247	A	$12.5366	15332	D ⁽¹⁾
Common Stock	9/15/2017		P		4253	A	$12.53	19585	D ⁽¹⁾
Common Stock	9/15/2017		P		400	A	$12.535	19985	D ⁽¹⁾
Common Stock	9/15/2017		P		2400	A	$12.55	22385	D ⁽¹⁾
Common Stock	9/15/2017		P		1951	A	$12.56	24336	D ⁽¹⁾
Common Stock	9/15/2017		P		2000	A	$12.57	26336	D ⁽¹⁾
Common Stock	9/15/2017		P		600	A	$12.5166	26936	D ⁽¹⁾
Common Stock	9/15/2017		P		300	A	$12.5498	27236	D ⁽¹⁾
Common Stock	9/15/2017		P		1200	A	$12.5766	28436	D ⁽¹⁾
Common Stock	9/15/2017		P		149	A	$12.5662	28585	D ⁽¹⁾
Common Stock	9/15/2017		P		194	A	$12.51	28779	D ⁽¹⁾
Common Stock	9/15/2017		P		400	A	$12.5162	29179	D ⁽¹⁾
Common Stock	9/15/2017		P		100	A	$12.515	29279	D ⁽¹⁾
Common Stock	9/15/2017		P		1200	A	$12.519	30479	D ⁽¹⁾
Common Stock	9/15/2017		P		306	A	$12.537	30785	D ⁽¹⁾
Common Stock	9/15/2017		P		300	A	$12.5761	31085	D ⁽¹⁾
Common Stock	9/15/2017		P		300	A	$12.6466	31385	D ⁽¹⁾
Common Stock	9/15/2017		P		600	A	$12.6166	31985	D ⁽¹⁾
Common Stock	9/15/2017		P		300	A	$12.6161	32285	D ⁽¹⁾
Common Stock	9/15/2017		P		300	A	$12.6232	32585	D ⁽¹⁾
Common Stock	9/15/2017		P		400	A	$12.6361	32985	D ⁽¹⁾

*Table II - Derivative Securities Beneficially Owned ( e.g.* , puts, calls, warrants, options, convertible securities)**
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)			11. Nature of Indirect Beneficial Ownership (Instr. 4)

Explanation of Responses:
(1)	Since the date of Mr. Coats' last ownership report, he transferred 17,782 shares of common stock to his ex-wife pursuant to a domestic relations order. Mr. Coats no longer reports as beneficially owned any securities owned by his ex-wife.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
COATS LONNEL 8800 TECHNOLOGY FOREST PLACE THE WOODLANDS, TX 77381	X		President and CEO

Signatures
/s/ Lonnel Coats		9/15/2017
^** Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:	File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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