FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Lichter Jay 		2. Issuer Name and Ticker or Trading Symbol

OTONOMY, INC. [ OTIC ] 		5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__ X __ Director                      _____ 10% Owner
_____ Officer (give title below)      _____ Other (specify below)
(Last)          (First)          (Middle)

C/O AVALON VENTURES, 1134 KLINE STREET 		3. Date of Earliest Transaction (MM/DD/YYYY)

8/31/2017
(Street)

LA JOLLA, CA 92037
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
6. Individual or Joint/Group Filing (Check Applicable Line)

_ X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock   8/31/2017     M (1)    141060   A $14.18   2406212   I   See Footnote   (2)
Common Stock   8/31/2017     F (1)    108851   D $18.37   2297361   I   See Footnote   (2)

Table II - Derivative Securities Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3) 		2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8) 		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4) 		8. Price of Derivative Security
(Instr. 5) 		9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Warrant to Purchase Common Stock (Right to Buy)   $14.18   8/31/2017     M   (1)       14106    8/18/2014   11/4/2018   Common Stock   14106   $0.00   0   I   See Footnote   (2)
Warrant to Purchase Common Stock (Right to Buy)   $14.18   8/31/2017     M   (1)       14106    8/18/2014   12/8/2018   Common Stock   14106   $0.00   0   I   See Footnote   (2)
Warrant to Purchase Common Stock (Right to Buy)   $14.18   8/31/2017     M   (1)       14106    8/18/2014   1/14/2019   Common Stock   14106   $0.00   0   I   See Footnote   (2)
Warrant to Purchase Common Stock (Right to Buy)   $14.18   8/31/2017     M   (1)       14106    8/18/2014   4/13/2019   Common Stock   14106   $0.00   0   I   See Footnote   (2)
Warrant to Purchase Common Stock (Right to Buy)   $14.18   8/31/2017     M   (1)       14106    8/18/2014   7/1/2019   Common Stock   14106   $0.00   0   I   See Footnote   (2)
Warrant to Purchase Common Stock (Right to Buy)   $14.18   8/31/2017     M   (1)       14106    8/18/2014   10/8/2019   Common Stock   14106   $0.00   0   I   See Footnote   (2)
Warrant to Purchase Common Stock (Right to Buy)   $14.18   8/31/2017     M   (1)       14106    8/18/2014   12/15/2019   Common Stock   14106   $0.00   0   I   See Footnote   (2)
Warrant to Purchase Common Stock (Right to Buy)   $14.18   8/31/2017     M   (1)       14106    8/18/2014   1/22/2020   Common Stock   14106   $0.00   0   I   See Footnote   (2)
Warrant to Purchase Common Stock (Right to Buy)   $14.18   8/31/2017     M   (1)       14106    8/18/2014   4/1/2020   Common Stock   14106   $0.00   0   I   See Footnote   (2)
Warrant to Purchase Common Stock (Right to Buy)   $14.18   8/31/2017     M   (1)       14106    8/18/2014   5/28/2020   Common Stock   14106   $0.00   0   I   See Footnote   (2)

Explanation of Responses:
(1)  On August 31, 2017, Avalon Ventures VIII, L.P. ("Avalon VIII LP") exercised certain warrants to purchase an aggregate of 141,060 shares of the Issuer's common stock at an exercise price of $14.18 per share. Avalon VIII LP paid the exercise price of the warrants on a cashless basis, resulting in the Issuer's withholding of 108,851 of the shares of common stock to pay the exercise price and the issuance to Avalon VIII LP of 32,209 shares.
(2)  The reported securities are held of record by Avalon VIII LP. The Reporting Person is a managing director of Avalon Ventures VIII GP, LLC, the general partner of Avalon VIII LP, and disclaims beneficial ownership of the securities held by Avalon VIII LP except to the extent of any pecuniary interest therein.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
Lichter Jay
C/O AVALON VENTURES
1134 KLINE STREET
LA JOLLA, CA 92037 		X



Signatures
/s/ Jay Lichter, Ph.D. 9/5/2017
** Signature of Reporting Person Date


Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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