FORM 5
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
[ ] Form 3 Holdings Reported
[ ] Form 4 Transactions Reported
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
ANNUAL STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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OMB Number: 3235-0362
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      
1. Name and Address of Reporting Person * Ranoux Claude 2. Issuer Name and Ticker or Trading Symbol INVO Bioscience, Inc. [ivob] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director                      __ X __ 10% Owner
_____ Officer (give title below)      _____ Other (specify below)
(Last)          (First)          (Middle)
8 CHESTNUT STREET
3. Statement for Issuer's Fiscal Year Ended (MM/DD/YYYY)
12/31/2018 
(Street)
WINCHESTER, MA 01890
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
6. Individual or Joint/Group Filing (Check Applicable Line) _ X _ Form Filed by One Reporting Person
___ Form Filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Amount (A) or (D) Price
INVO BIOSCIENCE Common Stock   2/21/2018     S   28662   D $0.114   25344164   D    
INVO BIOSCIENCE Common Stock   2/21/2018     S   10000   D $0.112   25334164   D    
INVO BIOSCIENCE Common Stock   2/21/2018     S   5000   D $0.114   25329164   D    
INVO BIOSCIENCE Common Stock   2/21/2018     S   30300   D $0.12   25298864   D    
INVO BIOSCIENCE Common Stock   2/23/2018     S   100   D $0.18   25298764   D    
INVO BIOSCIENCE Common Stock   2/28/2018     S   2000   D $0.18   25296764   D    
INVO BIOSCIENCE Common Stock   2/21/2018     S   1000   D $0.12   25295764   D    
INVO BIOSCIENCE Common Stock   3/5/2018     S   12642   D $0.19   25283122   D    
INVO BIOSCIENCE Common Stock   10/31/2018     A   910878   A $0.0001   26194000   D    
INVO BIOSCIENCE Common Stock   12/3/2018     I   1000000   D $0.0001   25194000   D    
INVO BIOSCIENCE Common Stock   12/3/2018     S   500000   D $0.05   24694000   D    

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
6. Date Exercisable and Expiration Date
(MM/DD/YYYY)
7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned at End of Issuer's Fiscal Year
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
(A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Explanation of Responses:

Remarks:
Second Form-5 for year 2018 concerning the last 11 transactions that were not reported in the first Form-5

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
Ranoux Claude
8 CHESTNUT STREET
WINCHESTER, MA 01890

X


Signatures
Claude Ranoux 2/1/2019
** Signature of Reporting Person Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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