UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of the
Securities Exchange Act of 1934

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Preliminary Proxy Statement

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Definitive Proxy Statement

Definitive Additional Materials

Soliciting Material Pursuant to §240.14a-12

ENZON PHARMACEUTICALS, INC.
(Name of Registrant as Specified in its Charter)

N/A
(Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)

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ENZON PHARMACEUTICALS, INC. c/o Continental Proxy Services   1 State Street, New York NY 10004   You May Vote Your Proxy When You View The   Material On The Internet. You Will Be Asked   To Follow The Prompts To Vote Your Shares.   Enzon Pharmaceuticals, Inc.   20 Commerce Drive, Suite 135   Cranford, New Jersey 07016   NOTICE OF ANNUAL MEETING   OF STOCKHOLDERS   to be held on Thursday,   August 22, 2019   *Stockholders are cordially invited to attend the 2019 Annual Meeting and vote in person.   Dear Stockholder,   The 2019 Annual Meeting of Stockholders (the “2019 Annual Meeting”) of Enzon Pharmaceuticals, Inc. (the “Company”) will be held at Club 101 on the Main Floor at 101 Park Avenue, New York, New York 10178 on Thursday, August 22, 2019 at 11:00 a.m., local time. Proposals to be considered at the 2019 Annual Meeting: (1) to elect three (3) directors, each for a one-year term expiring at the Company’s next annual meeting of stockholders and until such director’s successor is elected and qualified; (2) to ratify the appointment of EisnerAmper LLP as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2019; (3) to approve, on an advisory basis, the compensation of the Company’s named executive officers; and (4) to transact such other matters as may properly come before the 2019 Annual Meeting or any adjournment or postponement thereof. The Company’s Board of Directors has proposed and recommends that stockholders vote “FOR” each of the nominees to the Board of Directors listed in Proposal No. 1 and “FOR” Proposals Nos. 2 and 3. Your electronic vote authorizes the named proxies to vote your shares in the same   manner as if you marked, signed, dated, and returned the proxy card.   Vote Your Proxy on the Internet:   Go to http://www.cstproxyvote.com   Have your notice available when you   access the above website. Follow the   prompts to vote your shares.   The Proxy Statement and our Annual Report on   Form 10-K for the fiscal year ended December 31,   2018 are available online at: CONTROL NUMBER The Proxy Materials are available for review at:   http://www.cstproxy.com/enzon/2019




ENZON PHARMACEUTICALS, INC. 20 Commerce Drive, Suite 135   Cranford, New Jersey 07016   Important Notice Regarding the Availability of Proxy Materials For the   2019 Stockholder Meeting to Be Held On Thursday , August 22, 2019   This communication presents only an overview of the more complete proxy materials that are available to   you on the Internet. We encourage you to access and review all of the important information contained in   the proxy materials before voting.   If you would like to receive a paper or e mail copy of these documents, you must request one . There is no   charge for such documents to be mailed to you. Please make your request for a copy as instructed below   on or before July 30, 2019 to facilitate a timely delivery.   The following Proxy Materials for the 2019 Annual Meeting are available to you to review at:   http://www.cstproxy.com/enzon/2019   - the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2018;   - the Company’s Proxy Statement for the 2019 Annual Meeting;   - the Proxy Card for the 2019 Annual Meeting; and   – any amendments to the foregoing materials that are required to be furnished to stockholders.   You may contact the Company at (732) 980-4500 or through an e-mail request to investor@enzon.com for   directions to the 2019 Annual Meeting.   ACCESSING YOUR PROXY MATERIALS ONLINE Have this notice available when you request a paper copy of the proxy materials or to vote your proxy electronically. You must reference your company ID., proxy number, and account number. REQUESTING A PAPER COPY OF THE PROXY MATERIALS By telephone please call 1-888-221-0691, or By logging on to http://www.cstproxy.com/enzon/2019 or By email at: proxy@continentalstock.com   Please include the company name and your control number in the subject line.



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