Waters Otto SPEcialist Positive Pressure Manifold Improves Reproducibility and Reliability of Solid-Phase Extraction (SPE)
January 27 2021 - 08:00AM
Business Wire
Automation of a repetitive, but important, step
in the process of preparing samples for LC and LC-MS/MS analysis
enhances laboratory efficiency
NEWS SUMMARY:
- New Waters Otto SPEcialist Positive Pressure Manifold minimizes
user-to-user variability and improves reproducibility of analyte
recoveries
- Semi-automated system improves SPE workflows and enables
successful method transfer by automating an important aspect of
sample processing
- Otto SPEcialist simplifies method development for a variety of
applications
Waters Corporation (NYSE:WAT) today introduced the OttoTM
SPEcialist Positive Pressure Manifold designed to improve the
reliability and reproducibility of solid phase extraction (SPE).
Equipped with easy-to-use, 21 CFR Part 11 compliant software and
programmable pressure profiles, the Otto SPEcialist system provides
confidence in SPE results by eliminating common workflow errors,
reducing user variability, and documenting each method step to
remove uncertainty and prevent duplicative efforts. By automating
the various pressure applications of SPE, Otto helps laboratories
achieve greater overall efficiency and is useful for a variety of
pharmaceutical, biopharmaceutical food & beverage and
environmental applications.
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The Waters Otto SPEcialist Positive
Pressure Manifold is a software-driven, semi-automated system that
lets users program pressure profiles for more reliable and
repeatable solid phase extraction methods. (Photo: Business
Wire)
“Reproducible sample preparation is an essential component of
successful analytical methods” said Erin Chambers, Vice President,
Chemistry, Waters Corporation. “However, even straightforward
workflows like solid-phase extraction may suffer from poor
reproducibility due to technique-associated variation. Otto
SPEcialist is an important tool for helping laboratories perform
SPE in a controlled, reliable way. By reducing flow rate variation
and ensuring method fidelity regardless of user or experience
level, laboratories can more easily achieve success with ease while
scaling operations and resources seamlessly.”
For LC and LC-MS/MS analyses, sample preparation like SPE, is a
necessary first step best automated to ensure reliability and
reproducibility, especially when screening or analyzing significant
numbers of samples and when consistency is important. Controlled
with the intuitive, 21 CFR Part 11 compliant-ready Otto Software
through an integrated tablet, Otto SPEcialist system enables the
creation, editing, running, and sharing of pressure profiles and
methods with little-to-no training. By utilizing positive pressure
applied to the top of the device to control flow rather than vacuum
processing applied to the bottom, Otto SPEcialist system offers
more precise control for easier and more reliable sample
processing. The system provides a wide pressure control range,
accommodating a number of SPE device sizes and sorbent masses. The
Otto SPEcialist system also creates contact with each individual
cartridge or well, unlike vacuum processing where all cartridges or
wells are connected to a single source.
As compared to fully-automated SPE systems that are often
complicated and costly to set up and run, the semi-automated Otto
SPEcialist system – with easy-to-use software and a clean, simple
interface – can be quickly deployed without significant capital
investment. Users can create pressure profiles for every step of an
SPE workflow – including load, wash and elution steps – at the push
of a button. New and existing profiles, methods and processing
parameters are tracked and documented, allowing for unfettered
sharing across multiple days, users, laboratories, assays and Otto
devices. This eliminates the variability associated with manual
extraction procedures and ensures workflow consistency regardless
of operator or environment.
Otto SPEcialist system is compatible with a variety of sample
plates, including Waters 96-well plates as well as larger 1 cc, 3
cc, and 6 cc cartridges, to easily scale methods as needed.
Visit Waters’ website to learn more about the Otto SPEcialist
Positive Pressure Manifold for smart and controlled processing of
SPE, now available worldwide.
Additional Resources
- Download the white paper: Otto SPEcialist Positive Pressure
Manifold for Semi-Automated SPE Processing
- Download the infographic: Otto SPEcialist infographic
- Watch the video: Otto SPEcialist Positive Pressure Manifold –
How it Works
- For information about all of Waters products for laboratory
automation: Check out our web site.
- Request a demo or pricing
About Waters Corporation (www.waters.com)
Waters Corporation (NYSE:WAT), the world's leading specialty
measurement company, has pioneered chromatography, mass
spectrometry, and thermal analysis innovations serving the life,
materials, food and environmental sciences for more than 60 years.
With more than 7,000 employees worldwide, Waters operates directly
in 35 countries, including 15 manufacturing facilities, and with
products available in more than 100 countries.
Waters and Otto are trademarks of Waters Corporation.
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version on businesswire.com: https://www.businesswire.com/news/home/20210127005318/en/
Brian J. Murphy PR Manager, Corporate Communications Waters
Corporation brian_j_murphy@waters.com +1 508-482-2614
Staci Didner Account Supervisor PAN Communications
waters@pancomm.com
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