Initial Statement of Beneficial Ownership (3)

FORM 3	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0104 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^*

Boroditsky Marc

2. Date of Event Requiring Statement (MM/DD/YYYY) 12/15/2021

3. Issuer Name and Ticker or Trading Symbol

TWILIO INC [TWLO]

(Last) (First) (Middle)

C/O TWILIO INC., 101 SPEAR STREET, FIRST FLOOR

4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director _____ 10% Owner
___X___ Officer (give title below) _____ Other (specify below)
Chief Revenue Officer /

(Street)

SAN FRANCISCO, CA 94105

(City) (State) (Zip)

5. If Amendment, Date Original Filed(MM/DD/YYYY)

6. Individual or Joint/Group Filing(Check Applicable Line)

_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Class A Common Stock	61876 ⁽¹⁾	D

*Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)*
1. Title of Derivate Security (Instr. 4)	2. Date Exercisable and Expiration Date (MM/DD/YYYY)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivate Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security		6. Nature of Indirect Beneficial Ownership (Instr. 5)
Employee Stock Option (right to buy)	2/23/2019	3/11/2025	Class B Common Stock ⁽²⁾	46250.0	$7.07	D
Employee Stock Option (right to buy)	⁽³⁾	4/19/2028	Class A Common Stock	23154.0	$41.22	D
Employee Stock Option (right to buy)	⁽⁴⁾	2/19/2029	Class A Common Stock	24820.0	$116.3	D
Employee Stock Option (right to buy)	⁽⁵⁾	2/19/2030	Class A Common Stock	19514.0	$126.71	D
Employee Stock Option (right to buy)	⁽⁶⁾	4/19/2031	Class A Common Stock	12821.0	$367.65	D
Employee Stock Option (right to buy)	⁽⁷⁾	11/10/2031	Class A Common Stock	32373.0	$298.0	D

Explanation of Responses:
(1)	A portion of these shares represent Restricted Stock Units ("RSUs"). Each RSU represents a contingent right to receive one share of Issuer's Class A common stock.
(2)	Each share of Class B Common Stock is convertible into one share of Class A Common Stock at the option of the holder and has no expiration date.
(3)	This award originally represented an option to purchase 25,154 shares, of which 2,000 options have been exercised. The shares subject to this option vest in 48 equal monthly installments, with the first installment on June 15, 2018, subject to the Reporting Person's continued service to the Issuer through each vesting date.
(4)	The shares subject to this option vest in 48 equal monthly installments, with the first installment on March 15, 2019, subject to the Reporting Person's continued service to the Issuer through each vesting date.
(5)	The shares subject to this option vest in 48 equal monthly installments, with the first installment on March 15, 2020, subject to the Reporting Person's continued service to the Issuer through each vesting date.
(6)	The shares subject to this option vest 1/16th on May 15, 2021 then in 45 equal monthly installments, subject to the Reporting Person's continued service to the Issuer through each vesting date.
(7)	The shares subject to this option vest in 24 equal monthly installments, with the first installment on December 11, 2021, subject to the Reporting Person's continued service to the Issuer through each vesting date.

Remarks:
Exhibit 24 Power of Attorney

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
Boroditsky Marc C/O TWILIO INC. 101 SPEAR STREET, FIRST FLOOR SAN FRANCISCO, CA 94105			Chief Revenue Officer