Heat Biologics Sees Positive Data From Lung-Cancer-Treatment Trial

By Chris Wack

Heat Biologics Inc. said it saw positive interim data of its Phase 2 trial of HS-110 in combination with Bristol-Myers Squibb's Opdivo nivolumab in advanced non-small cell lung cancer.

The company's HS-110 is an "off-the-shelf" allogeneic cell-based therapy designed to activate patients' immune system against multiple cancer testis antigens to elicit a diverse and robust immune response against tumor cells.

Heat Biologics said substantial survival benefit was observed in a cohort of previously treated, checkpoint inhibitor naive patients with advanced non-small cell lung cancer.

A median progression free survival of 1.8 months and a median overall survival of 24.6 months was observed with a median follow-up time of 19.4 months. The one-year survival rate of cohort A is 61.7%.

For NSCLC patients who had previously been treated with a checkpoint inhibitor and whose disease had subsequently progressed, a median progression free survival of 2.8 months and median overall survival of 11.9 months was observed with a median follow-up time of 11.9 months.

The company said 30% of the patients in Cohort A and 26% of the patients in Cohort B are still alive. HS-110 has a favorable safety profile and has been administered in 200 patients to date. There have been no treatment-related serious adverse reactions. A review of immune-related adverse events reported in the study raised no safety concerns.

Heat Biologics shares were up 49%, to $12.48, in premarket trading.

Write to Chris Wack at chris.wack@wsj.com

(END) Dow Jones Newswires

February 09, 2021 08:29 ET (13:29 GMT)

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