FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      
1. Name and Address of Reporting Person * Squeri Stephen J 2. Issuer Name and Ticker or Trading Symbol AMERICAN EXPRESS CO [ AXP ] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable)__X__ Director                    _____ 10% Owner
__X__ Officer (give title below)    _____ Other (specify below)
Chairman and CEO
(Last)         (First)         (Middle)
200 VESEY STREET, AMERICAN EXPRESS TOWER
3. Date of Earliest Transaction (MM/DD/YYYY)
2/26/2021
(Street)
NEW YORK, NY 10285-5001
(City)       (State)       (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)
 
6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock  2/26/2021    M    21000  A $83.30  52285  D   
Common Stock  2/26/2021    M    48635  A $77.43  100920  D   
Common Stock  2/26/2021    S    68635  D $135.57 (1) 32285  D   
Common Stock  2/26/2021    S    1000  D $136.03 (2) 31285  D   
Common Stock  2/26/2021    J(3)    30000  D $136.02  175877 (3) I  by GRAT 
Common Stock  2/26/2021    J(3)    30000  A $136.02  61285 (3) D   
Common Stock  3/1/2021    G   V 30000  D  (4) 31285  D   
Common Stock                 123.37 (5) I  401(k) Trust 

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Employee Stock Option (Right to Buy)  $83.30  2/26/2021    M        21000   1/26/2018  1/26/2025  Common Stock  21000  $0  6777  D   
Employee Stock Option (Right to Buy)  $77.43  2/26/2021    M        48635   1/28/2020  1/28/2027  Common Stock  48635  $0  0  D   

Explanation of Responses:
(1)  The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $135.18 to $136.02, inclusive. The reporting person undertakes to provide to the Company, any security holder of the Company, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (1) and (2) to this Form 4.
(2)  The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $136.025 to $136.04, inclusive.
(3)  On February 26, 2021, the reporting person withdrew 30,000 shares of Company common stock from a grantor retained annuity trust established for the benefit of himself and his beneficiaries. In exchange for the shares, the reporting person contributed to the trust cash and securities with a value equal to $4,080,600. The withdrawal of shares from the trust resulted in a decrease in the number of shares the reporting person beneficially owns indirectly through the trust and a corresponding increase in the number of shares the reporting person beneficially owned directly. The reporting person believes that his withdrawal of shares from the trust constitutes a change in form of beneficial ownership of the shares, exempted by Rule 16a-13 under the Securities Exchange Act of 1934.
(4)  The reported disposition represents a bona fide charitable gift made by the reporting person.
(5)  Shares held in reporting person's account under the Company's Retirement Savings Plan. This plan uses unit accounting, and the number of shares that a participant is deemed to hold varies with the unit price of the Company pooled stock fund.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
Squeri Stephen J
200 VESEY STREET, AMERICAN EXPRESS TOWER
NEW YORK, NY 10285-5001
X
Chairman and CEO

Signatures
/s/ Kristina V. Fink, attorney-in-fact 3/2/2021
**Signature of Reporting Person Date