ST. PAUL, Minn., June 1, 2021 /PRNewswire/ -- 3M Health
Care launched 3M™ Harvest RC clarifier, leveraging its
proprietary fibrous chromatography media to deliver a single-stage
purification solution for recombinant protein therapeutic
manufacturing. It is the next generation in harvest and
clarification technology and is designed as an efficient option to
increase monoclonal antibody (mAb) yields while streamlining a
traditionally multi-stage harvest clarification process into a
single stage.
"As cell culture processes are intensified to yield higher cell
densities and product titers, the ability to effectively harvest
the cell culture fluid with the consistency and scalability
required becomes challenging," said Dr. Alexei Voloshin, global application development
manager, 3M Separation and
Purification Sciences. "The 3M
Harvest RC clarifier is an innovative solution that combats these
challenges while eliminating several steps to improve the
biopharmaceutical purification process."
With the capacity to support single-stage clarification across a
wide range of cultures with different cell densities, high packed
cell volumes, and cell culture characteristics, 3M Harvest RC clarifier will allow manufacturers
to achieve predictable performance, without programming every step.
3M Harvest RC clarifier is available
for discovery through commercial volumes.
This new technology provides multiple opportunities to support
upstream processes:
- High Yield: 3M Harvest RC
clarifier capsules consistently provide high mAb product recovery
(>95%).
- Optimized Upstream Harvest and Clarification Process:
3M Harvest RC clarifier condenses
three process steps into a single-stage chromatographic
purification step.
- Reliable Scalability: Precision quaternary ammonium (Q)
functionalized polypropylene fiber, combined with a 0.2 µm PES
membrane, provides scalable and predictable clarification from
discovery to commercial manufacturing scale.
- Consistent Effluent Quality: The 3M™ Harvest RC
clarifier introduces chromatographic separation earlier in the
process to remove soluble impurities, resulting in cleaner
effluent.
- Low Total Cost of Manufacturing: The manufacturing
flexibility, high yield, and condensed stages provide economic
benefits.
3M Separation and Purification Sciences Division utilizes
cutting edge 3M material science that pushes the
boundaries of purification, filtration, and separation to support
production, processes that change lives, and deliver quality
solutions where it matters most.
Individuals interested in learning more about the 3M Harvest RC clarifier are invited to contact
their regional sales representative at (800) 243-6894 or visit
www.3M.com/harvest.
About 3M
At 3M (NYSE: MMM), we apply science
in collaborative ways to improve lives daily as our employees
connect with customers all around the world. Learn more about 3M's
creative solutions to global challenges at www.3M.com or on Twitter
@3M or @3MNews.
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SOURCE 3M