81vette
2 years ago
Salarius Pharmaceuticals Announces Issuance of New U.S. Patent for Next-Generation Targeted Protein Degraders,announced 1/5/23,next greatest cure for cancer is possible>targeted protein inhibition and targeted protein degradation to develop therapies for patients with cancer in need of new treatment options, announces that on December 27, 2022 the U.S. Patent and Trademark Office (USPTO) issued U.S. Patent No. 11,535,603, titled โDeuterium-enriched Piperidinonyl-oxoisoindolinyl Acetamides and Methods of Treating Medical Disorders Using Same.โ The issued claims cover the composition of matter for novel molecular glue degraders including Salariusโ preclinical cereblon-binding compound, SP-3204, through September 2037.
Targeted protein degradation (TPD) takes advantage of the bodyโs own degradation system to promote the selective elimination of disease-causing proteins. The newly issued patent is based on the molecular glue eragidomide (CC-90009) that is known to target the degradation of GSPT1, a protein that is highly expressed in numerous cancers, including hematologic and solid tumors.
urge2surge
2 years ago
They may have started with good intentions but only a very few small bios ever materialize into something of real substance. Most are just ATM plays, banking off of hopeful and or naive investors. Took me a long time to see the forest from the trees. Better late than never. I monitor a lot of stocks and when I see weak bios issuing ATM I make a point to never re enter. A private placement is the best case scenario. They don't deserve my wallet or attentions thereafter. Eventually, with the market showing no signs of reversing for years to come, if at all, most will be delisted or bk. You can only play the investors to a certain point. With investors running for the exits, they'll be soon finding themselves with shut doors, as most won't be able to stay off creditors or debt liabilities. Good.
At this point in the pre hyper inflation recession period, I'm seeing an early return of monies into the OTC sector. Fwiw, here's a decent article on a few reward to risk plays that actually might produce some stellar returns. I know I can use it. Ugh...
https://insiderfinancial.com/4-otc-stocks-to-boost-your-portfolio-cybl-dpls-gmer-lclp/183146/
Glta
urge2surge
2 years ago
I've monitored this after making some coin a long time ago. Since then, been a dog and rightly so. Seeing a lot of small cap bios that have issued ATM at beaten down low stock prices. Why? Because they inherently have nothing of value to offer except sell shares, get a paycheck, and continue their facade. It's happening on a lot of these plays in this sector sad to say. Most should be delisted and or bought out primarily for the NOLS write offs to big pharma. Most of these dogs will and should fail. Anybody that knows anyone with cancer, knows that very little has changed beyond chemo and radiation. Despite all the monies supposedly spent on advancements, treatments haven't changed. Immunotherapy treatments are starting to gain treatment protocols, and experimental last ditch efforts on stem cells, but the majority is still chemo and radiation.
Anyways, I've sworn off these dead end oncology small bios, as little if any return on investments other than disappointments. I especially write off any that issue ATM at this sub $1 low of years prices. Looking at a reverse split followed by wash rinse and repeats. Corporate should be ashamed of themselves for terrible fiduciary management of shareholders monies. But they don't care. So vote with your wallet and find real companies with product and revenues. Let these dogs die as they should.
Glta
corvatsch
3 years ago
Salarius Pharmaceuticals to Present at the Diamond Equity Research Emerging Growth Invitational 2022 Virtual Conference
February 17 2022 - 02:01PM
GlobeNewswire Inc.
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Salarius Pharmaceuticals, Inc. (Nasdaq: SLRX), a clinical-stage biopharmaceutical company developing potential new medicines for patients with sarcomas, pediatric cancers, and other cancers, today announced that David Arthur, CEO of Salarius Pharmaceuticals, will present during the Diamond Equity Research Emerging Growth Invitational 2022 Virtual Conference on Thursday, February 24, 2022.
During the presentation, Mr. Arthur will highlight Salariusโ business and recent corporate achievements, including the ongoing Phase 1/2 clinical trial of seclidemstat and the companyโs recent purchase of a portfolio of targeted protein degradation assets, led by SP-3164.
corvatsch
3 years ago
Under the terms of the agreement, DeuteRx will receive from Salarius an upfront payment consisting of $1.5 million in cash and 1 million shares of restricted stock. Based upon the success of SP-3164, DeuteRx is also entitled to receive up to $53 million in future clinical and regulatory event-driven milestone payments and sales achievement milestone payments of up to $135 million, as well as escalating royalties on net sales. Additionally, DeuteRx is eligible to receive event-driven clinical, regulatory and sales achievement milestone payments of up to $84 million, as well as escalating royalties on net sales, for each of two future products.
hello AXELVENTO,
by this agreement, DeuteRx has a great advantage over SALARIUS. ? how do you see the situation in the medium term?
thank you.
axelvento
3 years ago
33 million in cash!!
'Seclidemstat also has the potential for treating various other cancer types. For instance, MD Anderson recently announced an investigator initiated trial studying seclidemstat in hematological cancers. In addition, Salarius hopes to study seclidemstat in other solid tumors in combination with immunotherapy or other targeted anti-cancer agents. And, with $33 million in cash as of June 30, 2021, it not only has the expertise but the financial ability to fund its clinical trials โ and build a pipeline supporting company growth โ for the future'.
$SLRX is looking to change the treatment paradigm by developing a less cytotoxic cancer treatment that is given as an oral tablet. Salariusโ treatment should not have the harsh side effects associated with chemotherapy, including hair loss and long-term nerve damage.
https://www.benzinga.com/general/biotech/21/10/23412584/could-the-future-hold-a-less-toxic-cancer-treatment-in-the-form-of-a-tablet?utm_campaign=partner_feed&utm_source=TechInvestorNews&utm_medium=partner_feed&utm_content=site