FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Snodgres Jon 		2. Issuer Name and Ticker or Trading Symbol

REPLIGEN CORP [ RGEN ] 		5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                      _____ 10% Owner
__ X __ Officer (give title below)      _____ Other (specify below)
CFO
(Last)          (First)          (Middle)

C/O REPLIGEN CORPORATION, 41 SEYON ST., BLDG 1, STE 100 		3. Date of Earliest Transaction (MM/DD/YYYY)

11/26/2018
(Street)

WALTHAM, MA 02453
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
6. Individual or Joint/Group Filing (Check Applicable Line)

_ X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock   11/26/2018     M    11445   A $26.20   32344   D    
Common Stock   11/26/2018     M    4000   A $24.50   36344   D    
Common Stock   11/26/2018     M    6055   A $32.40   42399   D    
Common Stock   11/26/2018     M    10253   A $26.05   52652   D    
Common Stock   11/26/2018     S    31753   (1) D $63.4874   (2) 20899   D    

Table II - Derivative Securities Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3) 		2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8) 		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4) 		8. Price of Derivative Security
(Instr. 5) 		9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (Right to Buy)   $26.20   11/26/2018     M         11445      (3) 2/26/2025   Common Stock   11445   $0.00   0   D    
Stock Option (Right to Buy)   $24.50   11/26/2018     M         4000      (4) 7/14/2024   Common Stock   4000   $0.00   2000   D    
Stock Option (Right to Buy)   $32.40   11/26/2018     M         6055      (5) 2/23/2027   Common Stock   6055   $0.00   12110   D    
Stock Option (Right to Buy)   $26.05   11/26/2018     M         10253      (6) 2/26/2026   Common Stock   10253   $0.00   5127   D    

Explanation of Responses:
(1)  Sale of common stock was effective pursuant to a 10(b)5-1 trading plan adopted on September 19, 2018.
(2)  $63.4874 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $63.18 to $64.71, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.
(3)  This option is currently exercisable.
(4)  2,000 shares vest and become exercisable on each of the following dates: 7/14/2015, 7/14/2016, 7/14/2017, 7/14/2018 and 7/14/2019.
(5)  6,055 shares vest and become exercisable on each of the following dates: 2/23/2018, 2/23/2019 and 2/23/2020.
(6)  Shares vest and become exercisable as follows: 5,126 shares on 2/26/2017, 5,127 shares on 2/26/2018 and 5,127 shares on 2/26/2019.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
Snodgres Jon
C/O REPLIGEN CORPORATION
41 SEYON ST., BLDG 1, STE 100
WALTHAM, MA 02453

CFO

Signatures
/s/ Jeffrey P. Leduc (Attorney in Fact) 11/28/2018
** Signature of Reporting Person Date


Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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