Horizon Therapeutics plc (Nasdaq: HZNP) announced today the opening of its new office in South San Francisco, located at 2 Tower Place, 12th floor. The 20,000 square-foot facility will feature laboratory space that will enable formulation and process development for manufacturing, as well as bioanalytical method development and other R&D functions.

“This is a significant step as we continue to grow our manufacturing and R&D capability to address patient needs through the development of groundbreaking therapies,” said Timothy Walbert, chairman, president and chief executive officer, Horizon. “We are excited to join the thriving life sciences community of South San Francisco, allowing us the opportunity to connect to newer technologies, leading academic institutions and the dynamic scientific area at large.”

“This new facility will allow us to function more seamlessly and efficiently as we expand our pipeline,” said Srini Ramanathan Ph.D., vice president, development sciences and site head for the South San Francisco, Horizon. “We look forward to exploring new partnerships in the South San Francisco biotech hub, and tapping into the wealth of talent in the area’s biotech and academic communities, as we develop new solutions to address needs in rare diseases and beyond.”

Horizon plans to add new positions in bioanalysis, clinical research, pharmacology, manufacturing and business development during the next year.

“Horizon brings nearly a decade of rare disease expertise to the Bay Area,” said Mike Guerra, president and chief executive officer of the California Life Sciences Association. “We welcome their addition to the over 3,400 life sciences companies in California, and eagerly await their contributions to California and the industry.”

About Horizon Therapeutics plc

Horizon is focused on researching, developing and commercializing medicines that address critical needs for people impacted by rare and rheumatic diseases. Our pipeline is purposeful: we apply scientific expertise and courage to bring clinically meaningful therapies to patients. We believe science and compassion must work together to transform lives. For more information on how we go to incredible lengths to impact lives, please visit www.horizontherapeutics.com, follow us @HorizonNews on Twitter, like us on Facebook or explore career opportunities on LinkedIn.

Forward-Looking Statements

This press release contains forward-looking statements, including, but not limited to, statements related to Horizon’s plans to expand its R&D capabilities, the potential benefits of its South San Francisco facilities; and business and other statements that are not historical facts. These forward-looking statements are based on Horizon’s current expectations and inherently involve significant risks and uncertainties. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of these risks and uncertainties, which include, without limitation, risks that Horizon’s actual future financial and operating results may differ from its expectations or goals; risks relating to Horizon’s ability to successfully implement its business strategies; risks inherent in developing novel medicine candidates; risks in the ability to recruit, train and retain qualified personnel; and those risks detailed from time-to-time under the caption "Risk Factors" and elsewhere in Horizon’s filings and reports with the SEC. Horizon undertakes no duty or obligation to update any forward-looking statements contained in this press release as a result of new information.

U.S. Media Contact: Geoff Curtis Executive Vice President, Corporate Affairs & Chief Communications Officer media@horizontherapeutics.com

Ireland Media Contact: Gordon MRM Ray Gordon ray@gordonmrm.ie

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