By Cara Lombardo and Jonathan D. Rockoff 

Gilead Sciences Inc. is nearing a deal to buy biotech Immunomedics Inc. and its prized breast-cancer drug for more than $20 billion, according to people familiar with the matter.

Immunomedics has a market value of roughly $10 billion following a recent surge in its stock, meaning that Gilead is paying up to secure ownership of the company.

A deal could be announced Monday if not sooner, assuming talks don't fall apart and a rival drugmaker doesn't jump in, some of the people said.

Immunomedics, based in Morris Plains, N.J., sells breast-cancer drug Trodelvy, which would be attractive to several large drugmakers, many of which have set their sights on adding more fast-growing oncology therapies to their portfolios.

Breast-cancer treatment is one of the most lucrative segments of the world-wide cancer-drugs market, which EvaluatePharma pegs at $157 billion this year. Trodelvy has shown signs of success in treating lung and other cancers too. At a medical conference this coming week, Immunomedics is expected to present data on Trodelvy's performance against bladder cancer.

In April, Trodelvy was approved in the U.S. to treat a form of the disease that has spread to other parts of the body and is known as triple-negative breast cancer.

Triple-negative breast cancer is an especially aggressive form of the disease that pharmaceutical companies have struggled to treat because it lacks the molecular targets that drugs can hone in on. It accounts for 10% to 15% of breast cancers, according to the American Cancer Society.

Discussions between Gilead and Immunomedics were initially centered around a partnership before shifting to a full-fledged takeover negotiation, some of the people said.

An acquisition would give Gilead -- an antiviral-drug leader that has been seeking for years to build up its portfolio of therapies for other diseases -- a foothold in the fast-growing cancer drug market. And Gilead doesn't take on any risk that regulators won't approve the drug, since they already have done it.

The Foster City, Calif., company is best known for its blockbuster hepatitis C offerings and HIV therapies. Most recently, Gilead has drawn notice for Covid-19 drug remdesivir, which the U.S. authorized for use in July and is expected to significantly boost the company's revenue this year.

Cancer drugs, however, promise to provide Gilead a more enduring business that could help the company offset declining sales of its hepatitis C drugs and competition for its HIV franchise.

Gilead Chief Executive Daniel O'Day, who took the helm in March 2019, has since been inking deals designed to bolster the company's portfolio. In 2019, it spent more than $5 billion deepening a partnership with Belgian biotech firm Galapagos NV. Earlier this year, it paid about $5 billion for biotech company Forty Seven Inc. and its blood-cancer drug.

Trodelvy belongs to a relatively new class of cancer agents called antibody drug conjugates. These drugs consist of an antibody that hunts down cancer cells and carries payloads of chemotherapy that is deployed to destroy the tumor target.

In 2017, Immunomedics had planned to sell the rights to the drug to biotech Seattle Genetics Inc., which specializes in antibody drug conjugates.

But activist investor venBio Select Advisor LLC, which then had a large stake in Immunomedics, stepped in and blocked the deal, saying it wasn't in investor interests. The husband-and-wife team that ran Immunomedics resigned from the company and the activist, now called Avoro Capital Advisors, gained representation on the company's board.

Avoro's Behzad Aghazadeh remains Immunomedics' chairman and Avoro owns a roughly 11% stake in the company, according to FactSet.

The company's history has been up and down since that battle. In 2019, the FDA postponed approval of Trodelvy, which Immunomedics said stemmed from chemistry and manufacturing issues. An FDA inspection found testing and record-keeping problems at the company's plant.

Immunomedics' share price is up 99% so far this year. Trodelvy rang up $20.1 million in net sales in its first two months on the market, which Jefferies & Co. analysts said indicated the drug could become a go-to treatment for triple-negative breast cancer. In 2022, Jefferies estimates, Trodelvy sales will reach $480 million.

Trodelvy could generate even more sales if trials under way find it works against other cancers, including another form of breast cancer known as HER2-negative and non-small cell lung cancer.

Write to Cara Lombardo at and Jonathan D. Rockoff at


(END) Dow Jones Newswires

September 12, 2020 15:46 ET (19:46 GMT)

Copyright (c) 2020 Dow Jones & Company, Inc.
Gilead Sciences (NASDAQ:GILD)
Historical Stock Chart
From Sep 2020 to Oct 2020 Click Here for more Gilead Sciences Charts.
Gilead Sciences (NASDAQ:GILD)
Historical Stock Chart
From Oct 2019 to Oct 2020 Click Here for more Gilead Sciences Charts.