FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      
1. Name and Address of Reporting Person * ORVILLE JACOB A 2. Issuer Name and Ticker or Trading Symbol EXACT SCIENCES CORP [ EXAS ] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable)_____ Director                    _____ 10% Owner
__X__ Officer (give title below)    _____ Other (specify below)
General Manager, New Ventures
(Last)         (First)         (Middle)
C/O EXACT SCIENCES CORP., 5505 ENDEAVOR LANE
3. Date of Earliest Transaction (MM/DD/YYYY)
2/18/2021
(Street)
MADISON, WI 53719
(City)       (State)       (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)
 
6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock  2/18/2021    M    3649 (1) A $0.00  7141  D   
Common Stock  2/19/2021    S    1696 (2) D $143.38  5445 (3) D   
Common Stock                 191  I  Held in 401(k) Plan 

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Restricted Stock Units   (4) 2/18/2021    M        3649    (5)  (5) Common Stock  3649  $0.00  7298  D   

Explanation of Responses:
(1)  Represents shares of common stock received upon vesting of a restricted stock unit award.
(2)  Represents shares sold pursuant to a Sell-to-Cover Rule 10b5-1 Plan to pay withholding taxes due in connection with the vesting of certain restricted stock units on February 18, 2021.
(3)  In addition to the shares of Common Stock reported on this Form 4, which total 5,636 shares, Mr. Orville also holds, in the aggregate, an additional 19,970 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock.
(4)  Each restricted stock unit represents a contingent right to receive one share of common stock.
(5)  Represents a restricted stock unit award that partially vested on February 18, 2021. The restricted stock units vest in four equal annual installments beginning on February 18, 2020.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
ORVILLE JACOB A
C/O EXACT SCIENCES CORP.
5505 ENDEAVOR LANE
MADISON, WI 53719


General Manager, New Ventures

Signatures
/s/ Jacob A. Orville by Mark R. Busch, attorney-in-fact 2/22/2021
**Signature of Reporting Person Date