Statement of Changes in Beneficial Ownership (4)

FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^* Presidio Management Group X LLC	2. Issuer Name and Ticker or Trading Symbol eFFECTOR Therapeutics, Inc. [ EFTR ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below)
(Last) (First) (Middle) 1460 EL CAMINO REAL, STE 100,	3. Date of Earliest Transaction (MM/DD/YYYY) 11/9/2021
(Street) MENLO PARK, CA 94025 (City) (State) (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) ___ Form filed by One Reporting Person _ X _ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Common Stock	11/9/2021		S		27892	D	$11.004 ⁽¹⁾	4644736	I	Directly owned by USVP X ⁽²⁾
Common Stock	11/9/2021		S		893	D	$11.004 ⁽¹⁾	148593	I	Directly owned by AFF X ⁽²⁾
Common Stock	11/10/2021		S		32946	D	$10.436 ⁽¹⁾	4611790	I	Directly owned by USVP X ⁽²⁾
Common Stock	11/10/2021		S		1054	D	$10.436 ⁽¹⁾	147539	I	Directly owned by AFF X ⁽²⁾
Common Stock	11/11/2021		S		11644	D	$10.368 ⁽¹⁾	4600146	I	Directly owned by USVP X ⁽²⁾
Common Stock	11/11/2021		S		373	D	$10.368 ⁽¹⁾	147166	I	Directly owned by AFF X ⁽²⁾
Common Stock	11/12/2021		S		11628	D	$10.07 ⁽¹⁾	4588518	I	Directly owned by USVP X ⁽²⁾
Common Stock	11/12/2021		S		372	D	$10.07 ⁽¹⁾	146794	I	Directly owned by AFF X ⁽²⁾

*Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)*
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)			11. Nature of Indirect Beneficial Ownership (Instr. 4)

Explanation of Responses:
(1)	The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $10.57 to $11.82, inclusive for sales on 11/9/21; prices ranging from $10.22 to $10.72, inclusive for sales on 11/10/21; prices ranging from $10.16 to $10.56, inclusive for sales on 11/11/21; and prices ranging from $10.00 to $10.22, inclusive for sales on 11/12/21. The reporting persons undertake to provide the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote to this Form 4
(2)	Presidio Management Group X, L.L.C. ("PMG X"), the general partner of each of U.S. Venture Partners X, L.P. ("USVP X") and USVP X Affiliates L.P. ("AFF X") (together, the "USVP X Funds"), has sole voting and dispositive power with respect to the shares held by the USVP X Funds. Casey Tansey is the sole managing partner of PMG X and may be deemed to have sole dispositive power over the reported securities held by the USVP X Funds and may be deemed to have shared voting power over the reported securities held by the USVP X Funds. Each of the foregoing persons disclaims beneficial ownership of such securities, except to the extent of any pecuniary interest therein.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
Presidio Management Group X LLC 1460 EL CAMINO REAL, STE 100 MENLO PARK, CA 94025		X
US VENTURE PARTNERS X LP 1460 EL CAMINO REAL, STE 100 MENLO PARK, CA 94025		X
USVP X AFFILIATES LP 1460 EL CAMINO REAL, STE 100 MENLO PARK, CA 94025		X
Tansey Casey M 1460 EL CAMINO REAL SUITE 100 MENLO PARK, CA 94025		X