Statement of Changes in Beneficial Ownership (4)

FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^* SAXE JON S	2. Issuer Name and Ticker or Trading Symbol DURECT CORP [ DRRX ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __ X __ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below)
(Last) (First) (Middle) 10260 BUBB ROAD	3. Date of Earliest Transaction (MM/DD/YYYY) 5/13/2019
(Street) CUPERTINO, CA 95014 (City) (State) (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) _ X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Common Stock	5/13/2019		P		200	A	$0.6804	45200	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		380	A	$0.6802	45580	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		2995	A	$0.6803	48575	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		287	A	$0.6814	48862	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		900	A	$0.6815	49762	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		699	A	$0.685	50461	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		200	A	$0.6881	50661	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		3100	A	$0.6898	53761	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		1195	A	$0.69	54956	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		489	A	$0.6902	55445	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		569	A	$0.6906	56014	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		779	A	$0.6911	56793	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		895	A	$0.694	57688	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		400	A	$0.6941	58088	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		1000	A	$0.6944	59088	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		1232	A	$0.6952	60320	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		4900	A	$0.6953	65220	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		300	A	$0.6972	65520	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		595	A	$0.6984	66115	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		1391	A	$0.7003	67506	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		1584	A	$0.7004	69090	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		864	A	$0.7005	69954	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		400	A	$0.7007	70354	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		4826	A	$0.7008	75180	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		1600	A	$0.7009	76780	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		1798	A	$0.701	78578	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		3900	A	$0.7019	82478	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		37	A	$0.702	82515	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		2085	A	$0.7027	84600	I	by Trust ⁽¹⁾
Common Stock	5/13/2019		P		800	A	$0.7035	85400	I	by Trust ⁽¹⁾

*Table II - Derivative Securities Beneficially Owned ( e.g.* , puts, calls, warrants, options, convertible securities)**
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)			11. Nature of Indirect Beneficial Ownership (Instr. 4)

Explanation of Responses:
(1)	Held by the Jon S. Saxe and Myrna G. Marshall 1997 Trust.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
SAXE JON S 10260 BUBB ROAD CUPERTINO, CA 95014	X

Signatures
Jon S. Saxe		5/14/2019
^** Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:	File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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