ALKS Alkermes PLC

[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES                                                                                   
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940                       

1. Name and Address of Reporting Person * FRATES JAMES M	2. Issuer Name and Ticker or Trading Symbol Alkermes plc. [ ALKS ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director                    _____ 10% Owner __X__ Officer (give title below)    _____ Other (specify below) SVP, Alks Inc; CFO ALKS
(Last)          (First)          (Middle) CONNAUGHT HOUSE, 1 BURLINGTON ROAD	3. Date of Earliest Transaction (MM/DD/YYYY) 9/13/2019
(Street) DUBLIN 4 Ireland (City)        (State)        (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Ordinary Shares	12/15/2017		G	V	2000	D	$0	38256 (1)	D
Ordinary Shares	9/13/2019		M		20000	A	$11.74	58256	D
Ordinary Shares								4000	I	By Sons
Ordinary Shares								1669	I	By 2018 GRAT No. 2 (2)
Ordinary Shares								150000	I	By 2019 GRAT No. 1 (3)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Employee Stock Option (Right to Buy)	$11.74	9/13/2019		M			20000	(4)	5/17/2020	Ordinary Shares	20000	$0	21983	D

Explanation of Responses:
(1)	Includes (a) 80,000 shares transferred to the Reporting Person on June 3, 2019 to satisfy an annuity payment from the Reporting Person's 2018 GRAT No. 1 (the James M. Frates Grantor Retained Annuity Trust dated February 22, 2018 and funded on February 23, 2018), and (b) 17,204 shares transferred to the Reporting Person on June 10, 2019 to satisfy an annuity payment from the Reporting Person's 2014 GRAT (the James M. Frates Grantor Retained Annuity Trust dated December 19, 2013 and funded on March 14, 2014), and (c) 43,331 shares transferred to the Reporting Person on June 11, 2019 to satisfy an annuity payment from the Reporting Person's 2018 GRAT No. 2 (the James M. Frates Grantor Retained Annuity Trust dated May 25, 2018 and funded on May 29, 2018), and excludes 150,000 shares previously owned directly, which were contributed on June 14, 2019 to the 2019 GRAT No. 1 (the James M. Frates 2019 Grantor Retained Annuity Trust No. 1 dated June 13, 2019), each of which transactions was exempt from the reporting obligations of Section 16 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), by virtue of Rule 16a-13 promulgated thereunder.
(2)	Shares held by the 2018 GRAT No. 2. The Reporting Person is a trustee and beneficiary of the 2018 GRAT No. 2 and may be deemed to hold voting and dispositive power with regard to the reported shares held by the 2018 GRAT No. 2.
(3)	Shares held by the 2019 GRAT No. 1. The Reporting Person is a trustee and beneficiary of the 2019 GRAT No. 1 and may be deemed to hold voting and dispositive power with regard to the reported shares held by the 2019 GRAT No. 1.
(4)	These options are fully vested in accordance with their terms.

Reporting Owners
Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
FRATES JAMES M CONNAUGHT HOUSE 1 BURLINGTON ROAD DUBLIN 4 Ireland			SVP, Alks Inc; CFO ALKS

Signatures
/s/ Jennifer Baptiste, attorney-in-fact for James M. Frates		9/17/2019
**Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:	File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.

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