This Amendment No. 2 (the Amendment) amends and supplements the
Solicitation/Recommendation Statement of Schedule 14D-9 (as amended or supplemented from time to time, the Schedule 14D-9) filed by Pfenex Inc., a
Delaware corporation (Pfenex or the Company), with the United States Securities Exchange Commission (the SEC) on August 31, 2020, relating to the tender offer (the
Offer) by Pelican Acquisition Sub, Inc., a Delaware corporation (Acquisition Sub) and a wholly owned subsidiary of Ligand Pharmaceuticals Incorporated, a Delaware corporation (Ligand), to
purchase all of the outstanding shares of common stock of Pfenex, par value $0.001 per share (the Shares) for a purchase price of (i) $12.00 per Share, in cash (the Cash Portion), and (ii) a non-transferrable contractual contingent value right per Share (a CVR), pursuant to the Contingent Value Rights Agreement (as it may be amended from time to time, the CVR
Agreement), to receive a contingent payment of $2.00 in cash upon the achievement of a specified milestone as set forth in the CVR Agreement (the CVR Portion, and together with the Cash Portion, the Offer
Price), without interest, subject to any required tax withholding and upon the terms and subject to the conditions set forth in Acquisition Subs Offer to Purchase, dated August 31, 2020 (the Offer to
Purchase), and in the related Letter of Transmittal (Letter of Transmittal), which, together with the Offer to Purchase and other related materials, as each may be amended, supplemented, or otherwise modified from time
to time in accordance with the Agreement and Plan of Merger, dated as of August 10, 2020, by and among Ligand, Acquisition Sub, and Pfenex (the Merger Agreement), constitute the Offer. The Offer is
described in the Tender Offer Statement on Schedule TO (as amended or supplemented from time to time, the Schedule TO) filed by Ligand and Acquisition Sub filed with the SEC on August 31, 2020. The Offer to Purchase and the
Letter of Transmittal are filed as Exhibits (a)(1)(A) and (a)(1)(B), respectively, to the Schedule 14D-9 and are incorporated herein by reference.
Except to the extent specifically provided in this Amendment, the information set forth in the Schedule 14D-9 remains
unchanged. Capitalized terms used herein but not otherwise defined shall have the meanings ascribed to them in the Schedule 14D-9. This Amendment is being filed to reflect certain updates as set forth below.
Item 3 of the Schedule 14D-9 is hereby amended as follows:
Item 3. Past Contacts, Transactions, Negotiations and Agreements.
On page 6, the paragraph under the heading Item 3. Past Contacts, Transactions, Negotiations and AgreementsArrangements with Directors and
Executive Officers of PfenexInterests of Certain Persons. is hereby amended and restated in its entirety as follows:
The executive
officers of Pfenex and the members of the Board may have interests in the Offer, the Merger and the other transactions contemplated by the Merger Agreement that are different from, or in addition to, the interests of Pfenexs stockholders,
generally. These interests may create potential conflicts of interest. Those interests include: (i) accelerated vesting and cash out of outstanding Company Options in connection with the Merger; (ii) in the case of executive officers,
enhanced severance benefits in the event of certain qualifying terminations of employment in connection with the closing of the Merger; and (iii) indemnification rights and benefits in their capacities as directors and officers of Pfenex. The
Board was aware of these interests and considered them, among other matters, in approving the Merger Agreement and the transactions contemplated thereby, as more fully discussed below in this Item 3. Past Contacts, Transactions, Negotiations
and Agreements and Item 4. The Solicitation or RecommendationRecommendation of the Board.