Initial Statement of Beneficial Ownership (3)

FORM 3	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0104 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^*

Clark Julie

2. Date of Event Requiring Statement (MM/DD/YYYY) 6/1/2021

3. Issuer Name and Ticker or Trading Symbol

Adverum Biotechnologies, Inc. [ADVM]

(Last) (First) (Middle)

C/O ADVERUM BIOTECHNOLOGIES, INC., 800 SAGINAW DRIVE

4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director _____ 10% Owner
___X___ Officer (give title below) _____ Other (specify below)
Chief Medical Officer /

(Street)

REDWOOD CITY, CA 94063

(City) (State) (Zip)

5. If Amendment, Date Original Filed(MM/DD/YYYY)

6. Individual or Joint/Group Filing(Check Applicable Line)

_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	49489 ⁽¹⁾	D

*Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)*
1. Title of Derivate Security (Instr. 4)	2. Date Exercisable and Expiration Date (MM/DD/YYYY)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivate Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security		6. Nature of Indirect Beneficial Ownership (Instr. 5)
Stock Option (Right to Buy)	⁽²⁾	5/14/2030	Common Stock	60000	$18.10	D
Stock Option (Right to Buy)	⁽³⁾	2/16/2031	Common Stock	33750	$13.44	D

Explanation of Responses:
(1)	Includes 46,125 Restricted Stock Units ("RSUs"). The Reporting Person is entitled to receive one (1) share of Common Stock of the Issuer for each one (1) RSU upon the vesting thereof, subject to the following vesting schedules: (A) 5,625 of such RSUs vest as to 1/4 of the shares subject thereto on each annual anniversary of February 16, 2021 and (B) 40,500 of such RSUs vest as to 1/3 of the shares subject thereto on the six-month anniversary of March 31, 2021 (the "3/31/21 RSU Vesting Commencement Date"), and the remaining 2/3 of the shares subject thereto shall vest on the one-year anniversary of the 3/31/21 RSU Vesting Commencement Date, in each case, subject to the Reporting Person's continued service with the Issuer on each such vesting date.
(2)	Twenty-five percent (25%) of the total number of shares subject to the option vested and became exercisable on the first anniversary of May 15, 2020 (the "2020 Option Vesting Commencement Date"), and 1/48 of the total number of shares subject to the option vest and become exercisable each month thereafter, such that all of the shares subject to the option shall become vested and exercisable as of the fourth anniversary of the 2020 Option Vesting Commencement Date, subject to the Reporting Person's continued service with the Issuer on each such vesting date.
(3)	Twenty-five percent (25%) of the total number of shares subject to the option vest and become exercisable on the first anniversary of February 16, 2021 (the "2021 Option Vesting Commencement Date"), and 1/48 of the total number of shares subject to the option vest and become exercisable each month thereafter, such that all of the shares subject to the option shall become vested and exercisable as of the fourth anniversary of the 2021 Option Vesting Commencement Date, subject to the Reporting Person's continued service with the Issuer on each such vesting date.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
Clark Julie C/O ADVERUM BIOTECHNOLOGIES, INC. 800 SAGINAW DRIVE REDWOOD CITY, CA 94063			Chief Medical Officer