(Amendment No. 2)*
Note: Schedules
filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See § 240.13d-7(b)
for other parties to whom copies are to be sent.
*The remainder
of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class
of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover
page.
The information
required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the
Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but
shall be subject to all other provisions of the Act (however, see the Notes).
CUSIP No. 00810B105
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1
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NAME OF REPORTING PERSON
OrbiMed Advisors LLC
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2
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CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
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(a) ☐
(b) ☐
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3
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SEC USE ONLY
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4
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SOURCE OF FUNDS
AF
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5
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CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)
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☐
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6
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CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
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NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
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7
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SOLE VOTING POWER
0
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8
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SHARED VOTING POWER
5,193,946
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9
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SOLE DISPOSITIVE POWER
0
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10
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SHARED DISPOSITIVE POWER
5,193,946
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11
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AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
5,193,946
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12
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CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions)
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☐
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13
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PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
11.0%*
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14
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TYPE OF REPORTING PERSON (See Instructions)
IA
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*
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This percentage is calculated based upon 47,111,659 outstanding shares of common stock, par value
$0.0001 per share (the “Shares”), of Aerpio Pharmaceuticals, Inc. (the “Issuer”), as set
forth in the Issuer’s quarterly report on Form 10-Q, filed with the Securities and Exchange Commission on November 10, 2020.
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CUSIP No. 00810B105
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1
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NAME OF REPORTING PERSON
OrbiMed Capital GP V LLC
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2
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CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
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(a) ☐
(b) ☐
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3
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SEC USE ONLY
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4
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SOURCE OF FUNDS
AF
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5
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CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)
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☐
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6
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CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
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NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
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7
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SOLE VOTING POWER
0
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8
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SHARED VOTING POWER
5,193,946
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9
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SOLE DISPOSITIVE POWER
0
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10
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SHARED DISPOSITIVE POWER
5,193,946
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11
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AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
5,193,946
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12
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CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions)
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☐
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13
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PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
11.0% *
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14
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TYPE OF REPORTING PERSON (See Instructions)
OO
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*
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This percentage is calculated based upon 47,111,659 outstanding shares of common stock, par value
$0.0001 per share (the “Shares”), of Aerpio Pharmaceuticals, Inc. (the “Issuer”), as set
forth in the Issuer’s quarterly report on Form 10-Q, filed with the Securities and Exchange Commission on November 10, 2020.
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Item 1.
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Security and Issuer
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This Amendment No.
2 (“Amendment No. 2”) to Schedule 13D supplements and amends the Statement on Schedule 13D of OrbiMed Advisors
LLC and OrbiMed Capital GP V LLC (the “Statement”) originally filed with the Securities and Exchange Commission
(the “SEC”) on March 27, 2017, as amended by Amendment No. 1 (“Amendment No. 1”) thereto
filed with the SEC on July 2, 2018. This Statement relates to the common stock, par value $0.0001 per share (the “Shares”),
of Aerpio Pharmaceuticals, Inc., a corporation organized under the laws of Delaware (the “Issuer”), with its
principal executive offices located at 9987 Carver Road, Cincinnati, OH 45242. The Shares are listed on the NASDAQ Capital Market
under the ticker symbol “ARPO.” Information given in response to each item shall be deemed incorporated by reference
in all other items, as applicable.
This Amendment No.
2 is being filed to report that the Issuer filed a quarterly report on Form 10-Q on November 10, 2020, which stated that the Issuer’s
total number of outstanding Shares had increased to 47,111,659 (the “Outstanding Share Increase”). As a result
of the Outstanding Share Increase, the percentage of outstanding Shares that the Reporting Persons may be deemed to beneficially
own was reduced by more than 1% since the filing of Amendment No. 1.
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Item 2.
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Identity and Background
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(a) This
Statement is being filed by OrbiMed Advisors LLC (“OrbiMed Advisors”), a limited liability company organized
under the laws of Delaware, and OrbiMed Capital GP V LLC (“GP V”), a limited liability company organized under
the laws of Delaware (collectively, the “Reporting Persons”).
(b) – (c),
(f) OrbiMed Advisors, a registered investment adviser under the Investment Advisers Act of 1940, as amended, is the managing
member of GP V, which is the general partner of OrbiMed Private Investments V, LP (“OPI V”), which holds Shares,
as described herein. OrbiMed Advisors and GP V have their principal offices at 601 Lexington Avenue, 54th Floor, New York, New
York 10022.
The directors and
executive officers of OrbiMed Advisors and GP V are set forth on Schedules I and II, attached hereto. Schedules I and II set forth
the following information with respect to each such person:
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(iii)
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present principal occupation or employment and the name, principal
business and address of any corporation or other organization in which such employment is conducted;
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(d) – (e) During
the last five years, neither the Reporting Persons nor any Person named in Schedule I or II have been (i) convicted in a criminal
proceeding (excluding traffic violations or similar misdemeanors) or (ii) a party to a civil proceeding of a judicial or administrative
body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining
future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation
with respect to such laws.
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Item 3.
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Source and Amount of Funds or Other Consideration
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Not applicable.
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Item 4.
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Purpose of Transaction
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The Shares have been
acquired by the Reporting Persons for the purpose of making an investment in the Issuer and not for the intention of acquiring
control of the Issuer’s business on behalf of OPI V.
The Reporting Persons
from time to time intend to review their investment in the Issuer on the basis of various factors, including the Issuer’s
business, financial condition, results of operations and prospects, general economic and industry conditions, the securities markets
in general and those for the Issuer’s Shares in particular, as well as other developments and other investment opportunities.
Based upon such review, the Reporting Persons will take such actions in the future as the Reporting Persons may deem appropriate
in light of the circumstances existing from time to time. If the Reporting Persons believe that further investment in the Issuer
is attractive, whether because of the market price of the Shares or otherwise, they may acquire Shares or other securities of the
Issuer either in the open market or in privately negotiated transactions. Similarly, depending on market and other factors, the
Reporting Persons may determine to dispose of some or all of the Shares currently owned by the Reporting Persons or otherwise acquired
by the Reporting Persons either in the open market or in privately negotiated transactions.
Except as set forth
in this Statement, the Reporting Persons have not formulated any plans or proposals which relate to or would result in: (a) the
acquisition by any person of additional securities of the Issuer or the disposition of securities of the Issuer, (b) an extraordinary
corporate transaction, such as a merger, reorganization or liquidation, involving the Issuer or any of its subsidiaries, (c) a
sale or transfer of a material amount of the assets of the Issuer or any of its subsidiaries, (d) any change in the present Board
of Directors or management of the Issuer, including any plans or proposals to change the number or term of directors or to fill
any existing vacancies on the board, (e) any material change in the Issuer’s capitalization or dividend policy of the Issuer,
(f) any other material change in the Issuer’s business or corporate structure, (g) any change in the Issuer’s charter
or bylaws or other instrument corresponding thereto or other action which may impede the acquisition of control of the Issuer by
any person, (h) causing a class of the Issuer’s securities to be deregistered or delisted from a national securities exchange
or to cease to be authorized to be quoted in an inter-dealer quotation system of a registered national securities association,
(i) a class of equity securities of the Issuer becoming eligible for termination of registration pursuant to Section 12(g)(4) of
the Act or (j) any action similar to any of those enumerated above.
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Item 5.
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Interest in Securities of the Issuer
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(a)
— (b) As of the date of this filing, the Reporting Persons
may be deemed, for purposes of Rule 13d-3 of the Act, directly or indirectly, including by reason of their mutual affiliation,
to be the beneficial owners of 5,193,946 Shares held of record by OPI V. Based upon information contained in the Issuer’s
Form 10-Q, filed with the Securities and Exchange Commission on November 10, 2020, such Shares constitutes approximately 11.0%
of the issued and outstanding Shares. OrbiMed Advisors, pursuant to its authority as the managing member of GP V, which is the
general partner of OPI V, may be deemed to indirectly beneficially own the Shares held by OPI V. GP V, pursuant to its authority
as the general partner of OPI V, may be deemed to indirectly beneficially own the Shares held by OPI V. As a result, OrbiMed Advisors
and GP V share the power to direct the vote and the disposition of the Shares held of record by OPI V. OrbiMed Advisors exercises
this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho, and Jonathan T. Silverstein,
each of whom disclaims beneficial ownership of the Shares held by OPI V.
(c) The
Reporting Persons has not effected any transaction during the past sixty (60) days in any Shares.
(d) Not
applicable.
(e) Not
applicable.
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Item 6.
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Contracts, Arrangements, Understandings or Relationship with Respect to Securities of the
Issuer
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In addition to the
relationships between the Reporting Persons described in Items 2, 3, and 5 above, GP V is the general partner of OPI V, pursuant
to the terms of the limited partnership agreement of OPI V. OrbiMed Advisors is the managing member of GP V, pursuant to the terms
of the limited liability company agreement of GP V. Pursuant to these agreements and relationships, OrbiMed Advisors and GP V have
discretionary investment management authority with respect to the assets of OPI V. Such authority includes the power of GP V and
OrbiMed Advisors to vote and otherwise dispose of securities purchased by OPI V. The number of outstanding Shares held of record
by OPI V is 5,193,946. OrbiMed Advisors and GP V may be considered to hold indirectly 5,193,946 Shares.
Registration Rights Agreement
OPI V and certain
other former stockholders of Aerpio Therapeutics are party to a registration rights agreement with the Issuer (the “Registration
Rights Agreement”), dated as of March 15, 2017. Pursuant to the Registration Rights Agreement and subject to the terms
and conditions therein, the parties agreed that:
Demand Registration Rights
The
holders of 30% majority of the shares covered by the Registration Rights Agreement,
or their transferees, can, on not more than two occasions, request that the Issuer register all or a portion of their shares. The
Issuer will not be required to effect a demand registration during the period that is 60 days before the Issuer’s good faith
estimate of the date of filing of, and ending on a date that is 180 days after the effective date of, a company-initiated registration
statement relating to an initial public offering of its securities, provided that the Issuer is actively employing in good faith
commercially reasonable efforts to cause such registration statement to become effective.
Piggyback Registration Rights
The Registration Rights
Agreement further provides that, in the event that the Issuer determines to register any of its securities under the Securities
Act of 1933, as amended (the “Securities Act”), either for its own account or for the account of other security
holders, the stockholders who are party to the Registration Rights Agreement, including OPI V, will be entitled to certain “piggyback”
registration rights allowing the holders to include their shares in such registration, subject to certain marketing and other limitations.
Form S-3 Registration Rights
At any time when the
Issuer is eligible to use a Form S-3 registration statement, the holders of at least 20% of the shares covered by the Registration
Rights Agreement or their transferees, can request that the Issuer register all or a portion of their shares on Form S-3. The Issuer
will not be required to effect a demand registration during the period that is 30 days before the Issuer’s good faith estimate
of the date of filing of, and ending on a date that is 90 days after the effective date of, a company-initiated registration of
its securities, provided that the Issuer is actively employing in good faith commercially reasonable efforts to cause such registration
statement to become effective. In addition, the Issuer shall not be required to file more than two registrations on Form S-3 in
any twelve-month period.
Termination of Registration Rights.
OPI V’s demand,
Form S-3 and piggyback registration rights described above generally will terminate upon the earlier of: (i) the
sale of all or substantially all of the assets of the Issuer on a consolidated basis to an unrelated person or entity, (ii) a
merger, reorganization or consolidation pursuant to which the holders of the Issuer’s outstanding voting power and outstanding
stock immediately prior to such transaction do not own a majority of the outstanding voting power and outstanding stock or other
equity interests of the resulting or successor entity immediately upon completion of such transaction, (iii) the sale of all
or substantially all of the Issuer’s assets or property to an unrelated person, entity or group, (iv) any other transaction
in which the owners of the Issuer’s outstanding voting power immediately prior to such transaction do not own at least a
majority of the outstanding voting power of the Issuer or any successor entity immediately upon completion of the transaction other
than as a result of the acquisition of securities directly from the Issuer, or (v) such time as all of the shares of the
Issuer held by OPI V may be sold without any restriction on volume or manner of sale in any three-month period pursuant to Rule
144 (or another similar exemption) under the Securities Act.
The foregoing description
of the Registration Rights Agreement does not purport to be complete and is qualified in its entirety by reference to the full
text of the Registration Rights Agreement, a copy of which is filed as Exhibit 2 and incorporated herein by reference.
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Item 7.
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Materials to Be Filed as Exhibits
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Exhibit
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Description
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1.
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Joint Filing Agreement among OrbiMed Advisors LLC and OrbiMed Capital GP V LLC.
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2.
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Registration Rights Agreement by and among Aerpio Pharmaceuticals, Inc. and certain former stockholders of Aerpio Therapeutics, Inc. signatory thereto (incorporated by reference to Exhibit 10.9 to the Issuer’s Form 8-K filed with the SEC (SEC File No. 000-53057) on March 17, 2017).
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SIGNATURE
After reasonable inquiry
and to the best of each of the undersigned’s knowledge and belief, each of the undersigned certifies that the information
set forth in this statement is true, complete and correct.
Dated: November 12, 2020
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OrbiMed Advisors LLC
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By:
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/s/ Jonathan T. Silverstein
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Name:
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Jonathan T. Silverstein
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Title:
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Member
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OrbiMed Capital GP V LLC
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By:
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OrbiMed Advisors LLC
its Managing Member
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By:
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/s/ Jonathan T. Silverstein
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Name:
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Jonathan T. Silverstein
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Title:
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Member of OrbiMed Advisors LLC
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Schedule I
The name and present principal occupation of
each of the executive officers and directors of OrbiMed Advisors LLC are set forth below. Unless otherwise noted, each
of these persons are United States citizens and have as their business address 601 Lexington Avenue, 54th Floor, New York, NY 10022.
Name
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Position with Reporting Person
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Principal Occupation
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Carl L. Gordon
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Member
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Member
OrbiMed Advisors LLC
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Sven H. Borho
German and Swedish Citizen
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Member
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Member
OrbiMed Advisors LLC
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Jonathan T. Silverstein
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Member
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Member
OrbiMed Advisors LLC
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W. Carter Neild
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Member
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Member
OrbiMed Advisors LLC
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Geoffrey C. Hsu
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Member
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Member
OrbiMed Advisors LLC
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C. Scotland Stevens
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Member
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Member
OrbiMed Advisors LLC
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David P. Bonita
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Member
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Member
OrbiMed Advisors LLC
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Trey Block
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Chief Financial Officer
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Chief Financial Officer
OrbiMed Advisors LLC
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Schedule II
The business and operations of OrbiMed Capital
GP V LLC are managed by the executive officers and directors of its managing member, OrbiMed Advisors LLC, set forth on Schedule
I.
EXHIBIT INDEX
Exhibit
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Description
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1.
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Joint Filing Agreement among OrbiMed Advisors LLC and OrbiMed Capital GP V LLC.
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2.
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Registration Rights Agreement by and among Aerpio Pharmaceuticals, Inc. and certain former stockholders of Aerpio Therapeutics, Inc. signatory thereto (incorporated by reference to Exhibit 10.9 to the Issuer’s Form 8-K filed with the SEC (SEC File No. 000-53057) on March 17, 2017).
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