FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Miller Andrew Craig
2. Issuer Name and Ticker or Trading Symbol

Karuna Therapeutics, Inc. [ KRTX ]
5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                    _____ 10% Owner
__X__ Officer (give title below)    _____ Other (specify below)
Chief Operating Officer
(Last)          (First)          (Middle)

C/O KARUNA THERAPEUTICS, INC., 33 ARCH ST STE 3110
3. Date of Earliest Transaction (MM/DD/YYYY)

11/10/2020
(Street)

BOSTON, MA 02110-1424
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
6. Individual or Joint/Group Filing (Check Applicable Line)

_X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 11/10/2020  M  4286 A$7.27 37286 D  
Common Stock 11/10/2020  S(1)  4286 D$103.8 33000 D  
Common Stock 11/10/2020  M  9047 A$9.2 42047 D  
Common Stock 11/10/2020  S(1)  9047 D$103.8 33000 D  
Common Stock 11/11/2020  M  8333 A$9.2 41333 D  
Common Stock 11/11/2020  S(1)  8333 D$100.01 33000 D  
Common Stock 11/12/2020  M  8334 A$9.2 41334 D  
Common Stock 11/12/2020  S(1)  8334 D$100 33000 D  

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security3. Trans. Date3A. Deemed Execution Date, if any4. Trans. Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
6. Date Exercisable and Expiration Date7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Option (right to buy) $7.27 11/10/2020  M     4286  9/15/2018 8/9/2028 Common Stock 4286 $0 19971 D  
Option (right to buy) $9.20 11/10/2020  M     9047  4/21/2019 3/21/2029 Common Stock 9047 $0 340016 D  
Option (right to buy) $9.20 11/11/2020  M     8333  4/21/2019 3/21/2029 Common Stock 8333 $0 331683 D  
Option (right to buy) $9.20 11/12/2020  M     8334  4/21/2019 3/21/2029 Common Stock 8334 $0 323349 D  

Explanation of Responses:
(1) The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
Miller Andrew Craig
C/O KARUNA THERAPEUTICS, INC.
33 ARCH ST STE 3110
BOSTON, MA 02110-1424


Chief Operating Officer

Signatures
/s/ Troy Ignelzi, Attorney-in-Fact11/12/2020
**Signature of Reporting PersonDate

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