The information contained in this prospectus is not complete and may be changed. These
securities may not be sold until the registration statement filed with the Securities and Exchange Commission is effective. This prospectus is not an offer to sell these securities and is not soliciting an offer to buy these securities in any
jurisdiction where the offer or sale is not permitted.
SUBJECT TO COMPLETION, DATED SEPTEMBER 2, 2020
PROSPECTUS SUPPLEMENT
(To Prospectus dated September , 2020)
TYME TECHNOLOGIES, INC.
$22,155,807
Common Stock
We have entered into an Open Market Sale
AgreementSM, or the Sale Agreement, dated October 18, 2019, as amended on August 12, 2020, with Jefferies LLC, or Jefferies, relating to shares of our common stock, $0.0001 par value per
share, offered by this prospectus supplement and the accompanying prospectus. In accordance with the terms of the Sale Agreement, we may offer and sell shares of our common stock having an aggregate offering price of up to $22,155,807 from time to
time through Jefferies, acting as sales agent, pursuant to this prospectus supplement and the accompanying prospectus. In addition, as of the date of this prospectus supplement, we had issued and sold shares of our common stock having an aggregate
offering price of $7,844,193 pursuant to the sales agreement under Registration Statement No. 333-211489, utilizing a prior prospectus dated August 8, 2017 and related prospectus supplement dated
October 18, 2019.
Upon our delivery of an issuance notice and subject to the terms and conditions of the Sale Agreement, Jefferies may sell the common
stock by any method permitted by law deemed to be an at the market offering as defined in Rule 415(a)(4) promulgated under the Securities Act of 1933, as amended, or the Securities Act, including block transactions, sales made directly
on The Nasdaq Capital Market or such other national securities exchange on which our shares of common stock are listed or sales made into any other existing trading market of our shares of common stock. In addition, with our prior written consent,
Jefferies may also sell the common stock by any other method permitted by law, including in privately negotiated transactions. Jefferies will act as sales agent using its commercially reasonable efforts consistent with its normal trading and sales
practices and applicable state and federal laws, rules and regulations and the rules of The Nasdaq Capital Market. There is no arrangement for funds to be received in any escrow, trust or similar arrangement.
We will pay Jefferies a commission, or allow a discount, for its services in acting as agent in the sale of common stock equal to 3.0% of the gross sales price per
share of all shares sold through it as agent under the Sale Agreement. See Plan of Distribution for information relating to certain expenses of Jefferies to be reimbursed by us.
In connection with the sale of common stock on our behalf, Jefferies may be deemed to be an underwriter within the meaning of the Securities Act and the
compensation to Jefferies will be deemed to be underwriting commissions or discounts. We have also agreed to provide indemnification and contribution to Jefferies with respect to certain liabilities, including liabilities under the Securities Act.
Our common stock is traded on The Nasdaq Capital Market under the symbol TYME. On August 31, 2020, the last reported sales price for our
common stock was $1.01 per share.
Investing in our common stock involves risks. See Risk Factors beginning on page
S-6 of this prospectus supplement and the discussion of risk factors contained in our annual, quarterly and current reports filed with the Securities and Exchange Commission under the Securities Exchange Act
of 1934, as amended, or the Exchange Act, which are incorporated by reference into this prospectus supplement and the accompanying prospectus.
Neither the
Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus supplement or the accompanying prospectus is truthful or complete. Any representation to the
contrary is a criminal offense.
Jefferies
The date of this prospectus supplement is September , 2020.