NOTICE OF CHANGE OF LOCATION
OF ANNUAL MEETING OF STOCKHOLDERS
TO BE HELD ON JUNE 24, 2020
TO THE
STOCKHOLDERS OF AERPIO PHARMACEUTICALS, INC.:
Due to the public health and safety concerns related to the novel coronavirus (COVID-19) pandemic, to support the health and well-being of the Companys stockholders, directors, employees and communities, NOTICE IS HEREBY GIVEN that the location of the 2020 Annual Meeting of Stockholders
(the Annual Meeting) of Aerpio Pharmaceuticals, Inc. (the Company) has been changed. In light of public health concerns regarding the COVID-19 outbreak, the Annual Meeting
will be held in a virtual meeting format only. The Annual Meeting will be accessible solely by means of remote communication, and stockholders will not be able to attend the Annual Meeting in person. As previously announced, the Annual Meeting will
be held on Wednesday, June 24, 2020 at 10:30 a.m., Eastern Time.
As described in the proxy materials for the Annual Meeting that were previously
distributed, you are entitled to participate in the Annual Meeting if you were a stockholder of the Company as of the close of business on April 27, 2020, the record date, or hold a legal proxy for the meeting provided by your bank, broker, or
nominee.
Instructions to Attend the Virtual Annual Meeting. To be admitted to the Annual Meeting at https://web.lumiagm.com/247499396, you
must enter: (i) the 11-digit control number found on the proxy card, voting instruction form, notice of internet availability of proxy materials or email, as applicable, previously sent or made available
to stockholders; and (ii) the meeting password aerpio2020. Please note the meeting password is case sensitive. Once you have completed these steps, select the login button, which will take you to the virtual annual
meeting page where you can vote, submit written questions and listen to the meeting.
Guest Access to the Audio Webcast of the Annual Meeting. If
you are a record holder and would like to enter the virtual annual meeting as a guest in listen-only mode, go to https://web.lumiagm.com/247499396 and select the button I am a guest. Please note you will not have the ability to
ask questions or vote during the meeting if you participate as a guest.
The live audio webcast of the Annual Meeting will begin promptly at 10:30 a.m.,
Eastern Time. Online access to the audio webcast will open 15 minutes prior to the start of the Annual Meeting to allow time for you to log-in and test your devices audio system. We encourage you to
access the meeting in advance of the designated start time.
Beneficial Owners. If you were a beneficial owner as of April 27, 2020 (i.e., you
hold your shares in street name through an intermediary, such as a bank, broker or other nominee), you must register in advance in order to attend the virtual annual meeting. To register, please obtain a legal proxy from the bank, broker
or other nominee that is the record holder of your shares and then submit the legal proxy, along with your name and email address, to AST to receive an 11-digit control number that may be used to access the
virtual annual meeting site provided above. While AST will continue to accept registrations up until the annual meeting, to facilitate registration for the virtual annual meeting, we ask and encourage you to send requests for registration and
submission of legal proxies, labeled as Legal Proxy, so that they are received by AST no later than 5 p.m., ET, on June 17, 2020. All such requests should be submitted (1) by email to proxy@astfinancial.com, (2) by
facsimile to (718) 765-8730, or (3) by mail to American Stock Transfer & Trust Company, LLC, Attn: Proxy Tabulation Department, 6201 15th Avenue, Brooklyn, NY 11219. Obtaining a legal proxy may
take several days and shareholders are advised to register as far in advance as possible. Once you have obtained your 11-digit control number from AST, please follow the steps set forth above for Record
Holders to attend the virtual annual meeting.
Asking Questions. If you are attending the virtual annual meeting as a stockholder of record
you can ask questions by clicking the messaging icon on the right side of the toolbar appearing at the top of the Meeting Page and then typing and submitting your question.
Voting Prior to or at the Annual Meeting. An online portal is available to stockholders at www.proxyvote.com where you can view and download our
proxy materials and Annual Report on Form 10-K for the fiscal year ended December 31, 2019 and vote your shares in advance of the Annual Meeting. If you are attending the Annual Meeting as a stockholder
of record you can vote during the meeting by clicking the link Proxy Voting Site on the Meeting Page and following the prompts.