TIDMSHP 
 
 
   BLOCK LISTING SIX MONTHLY RETURN 
 
   November 24, 2017 - Shire plc (LSE: SHP, NASDAQ: SHPG) 
 
 
 
 
Name of applicant:                                              Shire plc 
Name of scheme:                                                 Shire Sharesave Scheme 
                                                                                    November 22, 
Period of return:                     From:                     May 23, 2017  To:   2017 
Balance of unallotted securities under scheme(s) from 
 previous return:                                                                        167,532 
Plus: The amount by which the block scheme(s) has 
 been increased since the date of the last return (if 
 any increase has been applied for):                                                         Nil 
Less: Number of securities issued/allotted under scheme(s) 
 during period (see LR3.5.7G):                                                             4,012 
Equals: Balance under scheme(s) not yet issued/allotted 
 at end of period:                                                                       163,520 
 
 
 
 
 
 
 
Name of applicant:                                              Shire plc 
Name of scheme:                                                 Shire Portfolio Share Plan 
                                                                                   November 22, 
Period of return:                     From:                     May 23, 2017  To:  2017 
Balance of unallotted securities under scheme(s) from 
 previous return:                                                                        360,742 
Plus: The amount by which the block scheme(s) has 
 been increased since the date of the last return (if 
 any increase has been applied for):                                                         Nil 
Less: Number of securities issued/allotted under scheme(s) 
 during period (see LR3.5.7G):                                                            90,208 
Equals: Balance under scheme(s) not yet issued/allotted 
 at end of period:                                                                       270,534 
 
 
 
 
Name of applicant:                                              Shire plc 
                                                                Shire Employee Stock Purchase 
Name of scheme:                                                 Plan 
                                                                                    November 22, 
Period of return:                     From:                     May 23, 2017   To:  2017 
Balance of unallotted securities under scheme(s) from 
 previous return:                                                                        237,698 
Plus: The amount by which the block scheme(s) has 
 been increased since the date of the last return (if 
 any increase has been applied for):                                                         Nil 
Less: Number of securities issued/allotted under scheme(s) 
 during period (see LR3.5.7G):                                                               Nil 
Equals: Balance under scheme(s) not yet issued/allotted 
 at end of period:                                                                       237,698 
 
 
 
 
Name of applicant:                                              Shire plc 
                                                                Shire Long Term Incentive Plan 
Name of scheme:                                                 2015 
                                                                                    November 22, 
Period of return:                     From:                     May 23, 2017   To:  2017 
Balance of unallotted securities under scheme(s) from 
 previous return:                                                                      2,687,072 
Plus: The amount by which the block scheme(s) has 
 been increased since the date of the last return (if 
 any increase has been applied for):                                                         Nil 
Less: Number of securities issued/allotted under scheme(s) 
 during period (see LR3.5.7G):                                                           188,501 
Equals: Balance under scheme(s) not yet issued/allotted 
 at end of period:                                                                     2,498,571 
 
 
 
 
Name of applicant:                                              Shire plc 
                                                                Shire Global Employee Stock 
Name of scheme:                                                 Purchase Plan 
                                                                                    November 22, 
Period of return:                     From:                     May 23, 2017  To:   2017 
Balance of unallotted securities under scheme(s) from 
 previous return:                                                                      1,600,843 
Plus: The amount by which the block scheme(s) has 
 been increased since the date of the last return (if 
 any increase has been applied for):                                                         Nil 
Less: Number of securities issued/allotted under scheme(s) 
 during period (see LR3.5.7G):                                                           800,060 
Equals: Balance under scheme(s) not yet issued/allotted 
 at end of period:                                                                       800,783 
 
 
 
 
Name of applicant:                                              Shire plc 
Name of scheme:                                                 Baxalta Exchange Awards 
                                                                                   November 22, 
Period of return:                     From:                     May 23, 2017  To:  2017 
Balance of unallotted securities under scheme(s) from 
 previous return:                                                                     17,995,867 
Plus: The amount by which the block scheme(s) has 
 been increased since the date of the last return (if 
 any increase has been applied for):                                                         Nil 
Less: Number of securities issued/allotted under scheme(s) 
 during period (see LR3.5.7G):                                                           765,528 
Equals: Balance under scheme(s) not yet issued/allotted 
 at end of period:                                                                    17,230,339 
 
 
 
 
Name of applicant:                                              Shire plc 
                                                                Combined block listing in respect of the Shire Portfolio 
                                                                 Share Plan, the Shire Long Term Incentive Plan 2015 
Name of scheme:                                                  and the Shire Global Employee Stock Purchase Plan. 
Period of return:                     From:                     July 7, 2017          To:       November 22, 2017 
Balance of unallotted securities under scheme(s) from 
 previous return:                                               N/A 
Plus: The amount by which the block scheme(s) has 
 been increased since the date of the last return (if 
 any increase has been applied for):                                                                               3,000,000 
                                                                                             Shire Portfolio Share Plan: Nil 
Less: Number of securities issued/allotted under scheme(s)                          Shire Long Term Incentive Plan 2015: Nil 
 during period (see LR3.5.7G):                                                Shire Global Employee Stock Purchase Plan: Nil 
Equals: Balance under scheme(s) not yet issued/allotted 
 at end of period:                                                                                                 3,000,000 
 
 
   Amendment of Block listing six monthly return released May 23, 2017: 
 
   November 24, 2017 - Shire plc (LSE: SHP, NASDAQ: SHPG) announces that 
the Block listing six monthly return released May 23, 2017, has been 
amended to reflect the following: 
 
   The number of securities issued/allotted under the Shire Portfolio Share 
Plan is amended from 405,083 to 408,873 and the balance not yet 
issued/allotted under this scheme is amended from 364,532 to 360,742. 
 
   The number of securities issued/allotted under the Shire Long Term 
Incentive Plan 2015 is amended from 145,740 to 149,340 and the balance 
not yet issued/allotted under this scheme is amended from 2,690,672 to 
2,687,072. 
 
   The full amended announcement is below. 
 
   May 23, 2017 - Shire plc (LSE: SHP, NASDAQ: SHPG) 
 
 
 
 
Name of applicant:                                              Shire plc 
Name of scheme:                                                 Shire Sharesave Scheme 
                                                                November 23, 
Period of return:                     From:                     2016          To:   May 22, 2017 
Balance of unallotted securities under scheme(s) from 
 previous return:                                                                        184,611 
Plus: The amount by which the block scheme(s) has 
 been increased since the date of the last return (if 
 any increase has been applied for):                                                         Nil 
Less: Number of securities issued/allotted under scheme(s) 
 during period (see LR3.5.7G):                                                            17,079 
Equals: Balance under scheme(s) not yet issued/allotted 
 at end of period:                                                                       167,532 
 
 
 
 
 
 
 
Name of applicant:                                              Shire plc 
Name of scheme:                                                 Shire Portfolio Share Plan 
                                                                November 23, 
Period of return:                     From:                     2016           To:  May 22, 2017 
Balance of unallotted securities under scheme(s) from 
 previous return:                                                                        769,615 
Plus: The amount by which the block scheme(s) has 
 been increased since the date of the last return (if 
 any increase has been applied for):                                                         Nil 
Less: Number of securities issued/allotted under scheme(s) 
 during period (see LR3.5.7G):                                                           408,873 
Equals: Balance under scheme(s) not yet issued/allotted 
 at end of period:                                                                       360,742 
 
 
 
 
 
 
 
Name of applicant:                                              Shire plc 
                                                                Shire Employee Stock Purchase 
Name of scheme:                                                 Plan 
                                                                November 23, 
Period of return:                     From:                     2016           To:  May 22, 2017 
Balance of unallotted securities under scheme(s) from 
 previous return:                                                                        244,057 
Plus: The amount by which the block scheme(s) has 
 been increased since the date of the last return (if 
 any increase has been applied for):                                                         Nil 
Less: Number of securities issued/allotted under scheme(s) 
 during period (see LR3.5.7G):                                                             6,359 
Equals: Balance under scheme(s) not yet issued/allotted 
 at end of period:                                                                       237,698 
 
 
 
 
Name of applicant:                                              Shire plc 
                                                                Shire Long Term Incentive Plan 
Name of scheme:                                                 2015 
                                                                November 23, 
Period of return:                     From:                     2016          To:  May 22, 2017 
Balance of unallotted securities under scheme(s) from 
 previous return:                                                                      2,836,412 
Plus: The amount by which the block scheme(s) has 
 been increased since the date of the last return (if 
 any increase has been applied for):                                                         Nil 
Less: Number of securities issued/allotted under scheme(s) 
 during period (see LR3.5.7G):                                                           149,340 
Equals: Balance under scheme(s) not yet issued/allotted 
 at end of period:                                                                     2,687,072 
 
 
 
 
Name of applicant:                                              Shire plc 
                                                                Shire Global Employee Stock 
Name of scheme:                                                 Purchase Plan 
                                                                November 23, 
Period of return:                     From:                     2016          To:   May 22, 2017 
Balance of unallotted securities under scheme(s) from 
 previous return:                                                                      1,604,243 
Plus: The amount by which the block scheme(s) has 
 been increased since the date of the last return (if 
 any increase has been applied for):                                                         Nil 
Less: Number of securities issued/allotted under scheme(s) 
 during period (see LR3.5.7G):                                                             3,400 
Equals: Balance under scheme(s) not yet issued/allotted 
 at end of period:                                                                     1,600,843 
 
 
 
 
Name of applicant:                                              Shire plc 
Name of scheme:                                                 Baxalta Exchange Awards 
                                                                November 23, 
Period of return:                     From:                     2016           To:  May 22, 2017 
Balance of unallotted securities under scheme(s) from 
 previous return:                                                                     20,488,204 
Plus: The amount by which the block scheme(s) has 
 been increased since the date of the last return (if 
 any increase has been applied for):                                                         Nil 
Less: Number of securities issued/allotted under scheme(s) 
 during period (see LR3.5.7G):                                                         2,492,337 
Equals: Balance under scheme(s) not yet issued/allotted 
 at end of period:                                                                    17,995,867 
 
 
 
 
Name of contact:               Sarah Rixon, Company Secretarial Assistant 
Telephone number of contact:                                 01256 894000 
 
 
   For further information please contact: 
 
 
 
 
Investor Relations 
Ian Karp             ikarp@shire.com         +1 781 482 9018 
Robert Coates        rcoates@shire.com      +44 203 549 0874 
Media 
Lisa Adler           lisa.adler@shire.com    +1 617 588 8607 
Katie Joyce          kjoyce@shire.com        +1 781 482 2779 
 
 
   NOTES TO EDITORS 
 
   About Shire 
 
   Shire is the global leader in serving patients with rare diseases. We 
strive to develop best-in-class therapies across a core of rare disease 
areas including hematology, immunology, genetic diseases, neuroscience, 
and internal medicine with growing therapeutic areas in ophthalmics and 
oncology. Our diversified capabilities enable us to reach patients in 
more than 100 countries who are struggling to live their lives to the 
fullest. 
 
   We feel a strong sense of urgency to address unmet medical needs and 
work tirelessly to improve people's lives with medicines that have a 
meaningful impact on patients and all who support them on their journey. 
 
   www.shire.com 
 
   This announcement is distributed by Nasdaq Corporate Solutions on behalf 
of Nasdaq Corporate Solutions clients. 
 
   The issuer of this announcement warrants that they are solely 
responsible for the content, accuracy and originality of the information 
contained therein. 
 
   Source: Shire plc via Globenewswire 
 
 
 
 

(END) Dow Jones Newswires

November 24, 2017 10:15 ET (15:15 GMT)

Copyright (c) 2017 Dow Jones & Company, Inc.
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