FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

HOFFMANN DAVE 		2. Issuer Name and Ticker or Trading Symbol

DURECT CORP [ DRRX ] 		5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__ X __ Director                      _____ 10% Owner
_____ Officer (give title below)      _____ Other (specify below)
(Last)          (First)          (Middle)

10260 BUBB ROAD 		3. Date of Earliest Transaction (MM/DD/YYYY)

9/21/2017
(Street)

CUPERTINO, CA 95014
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
6. Individual or Joint/Group Filing (Check Applicable Line)

_ X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock   9/21/2017     M    35000   A $1.19   60000   D    
Common Stock   9/21/2017     M    35000   A $1.05   95000   D    
Common Stock   9/21/2017     M    25000   A $0.8198   120000   D    
Common Stock                  248000   I   by Trust   (1)

Table II - Derivative Securities Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3) 		2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8) 		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4) 		8. Price of Derivative Security
(Instr. 5) 		9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Non-Qualified Stock Option (right to buy)   $0.8198   9/21/2017     M         25000    6/19/2013   (2) 6/20/2022   Common Stock   25000   $0.0   0   D    
Non-Qualified Stock Option (right to buy)   $1.05   9/21/2017     M         35000    6/24/2014   (3) 6/25/2023   Common Stock   35000   $0.0   0   D    
Non-Qualified Stock Option (right to buy)   $1.19   9/21/2017     M         35000    6/21/2017   (4) 6/22/2026   Common Stock   35000   $0.0   0   D    

Explanation of Responses:
(1)  Held by David R. and Judy A. Hoffmann, Co-Trustees for the David R. and Judy A Hoffmann Trust UD 11/14/79.
(2)  100% of the total shares of this Grant Dated June 20, 2012 shall vest on the day before the first year anniversary of the Grant Date.
(3)  100% of the total shares of this Grant Dated June 25, 2013 shall vest on the day before the first year anniversary of the Grant Date.
(4)  100% of the total shares of this Grant Dated June 22, 2016 shall vest on the day before the first year anniversary of the Grant Date.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
HOFFMANN DAVE
10260 BUBB ROAD
CUPERTINO, CA 95014 		X



Signatures
David R. Hoffmann 9/21/2017
** Signature of Reporting Person Date


Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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