FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

BIBERSTEIN KATHRYN L
2. Issuer Name and Ticker or Trading Symbol

Alkermes plc. [ ALKS ]
5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                      _____ 10% Owner
__ X __ Officer (give title below)      _____ Other (specify below)
EVP/CAO/CCO Alks Inc; Sec ALKS
(Last)          (First)          (Middle)

852 WINTER ST.
3. Date of Earliest Transaction (MM/DD/YYYY)

9/11/2017
(Street)

WALTHAM, MA 02451
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
6. Individual or Joint/Group Filing (Check Applicable Line)

_ X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Ordinary Shares   9/11/2017     M (1)    13566   A $14.13   70455   D    
Ordinary Shares   9/11/2017     S (2)    11067   D $51.1826   (3) 59388   D    
Ordinary Shares   9/11/2017     S (2)    2499   D $51.7724   (4) 56889   D    
Ordinary Shares                  36848   I   By 2015 GRAT   (5)
Ordinary Shares                  57152   I   By 2016 GRAT   (6)

Table II - Derivative Securities Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Employee Stock Option (Right to Buy)   $14.13   9/11/2017     M   (1)       13566      (7) 11/5/2017   Ordinary Shares   13566   $0   0   D    

Explanation of Responses:
(1)  This option exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 11/23/16.
(2)  This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 11/23/16.
(3)  The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $50.55 to $51.54. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
(4)  The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $51.605 to $51.91. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request. Cancel
(5)  Shares held by the Kathryn L. Biberstein 2015 Annuity Trust dated December 11, 2015 (the "2015 GRAT"). The Reporting Person is a trustee and beneficiary of the 2015 GRAT and may be deemed to hold voting and dispositive power with regard to the reported shares held by the 2015 GRAT.
(6)  Shares held by the Kathryn L. Biberstein 2016 Annuity Trust dated December 9, 2016 (the "2016 GRAT"). The Reporting Person is a trustee and beneficiary of the 2016 GRAT and may be deemed to hold voting and dispositive power with regard to the reported shares held by the 2016 GRAT.
(7)  These options are fully vested in accordance with their terms.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
BIBERSTEIN KATHRYN L
852 WINTER ST.
WALTHAM, MA 02451


EVP/CAO/CCO Alks Inc; Sec ALKS

Signatures
/s/ Jennifer Baptiste, attorney-in-fact for Kathryn L. Biberstein 9/13/2017
** Signature of Reporting Person Date


Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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