FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

LEDERMAN SETH
2. Issuer Name and Ticker or Trading Symbol

Tonix Pharmaceuticals Holding Corp. [ TNXP ]
5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__ X __ Director                      _____ 10% Owner
__ X __ Officer (give title below)      _____ Other (specify below)
Chief Executive Officer
(Last)          (First)          (Middle)

C/O TONIX PHARMACEUTICALS HOLDING CORP, 509 MADISON AVE., SUITE 306
3. Date of Earliest Transaction (MM/DD/YYYY)

8/16/2017
(Street)

NEW YORK, NY 10022
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
6. Individual or Joint/Group Filing (Check Applicable Line)

_ X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock, $0.001 par value   8/16/2017     P    5000   A $2.99   35000   I   By IRA account  
Common Stock, $0.001 par value   8/17/2017     P    15000   A $3.0045   50000   I   By IRA account  
Common Stock, $0.001 par value                  13300   I   By 401(k) plan  
Common Stock, $0.001 par value                  11166   D    
Common Stock, $0.001 par value                  3100   I   By spouse  
Common Stock, $0.001 par value                  2.917   I   By Leder Laboratories, Inc.   (1)
Common Stock, $0.001 par value                  2917   I   By Starling Pharmaceuticals, Inc.   (1)
Common Stock, $0.001 par value                  18463   I   By Lederman & Co., LLC   (1)
Common Stock, $0.001 par value                  3246   I   By L&L Technologies, LLC   (1)
Common Stock, $0.001 par value                  5898   I   By Targent Pharmaceuticals, LLC   (1)

Table II - Derivative Securities Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Explanation of Responses:
(1)  Reporting person may be deemed to be a control person of this entity.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
LEDERMAN SETH
C/O TONIX PHARMACEUTICALS HOLDING CORP
509 MADISON AVE., SUITE 306
NEW YORK, NY 10022
X
Chief Executive Officer

Signatures
/s/ Jessica Morris, Attorney-in-Fact 8/18/2017
** Signature of Reporting Person Date


Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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