Initial Statement of Beneficial Ownership (3)

FORM 3	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0104 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^*

Humphrey David Carl

2. Date of Event Requiring Statement (MM/DD/YYYY) 6/9/2017

3. Issuer Name and Ticker or Trading Symbol

SENOMYX INC [SNMX]

(Last) (First) (Middle)

4767 NEXUS CENTRE DR.

4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director _____ 10% Owner
___ X ___ Officer (give title below) _____ Other (specify below)
Vice President, Finance /

(Street)

SAN DIEGO, CA 92121

(City) (State) (Zip)

5. If Amendment, Date Original Filed (MM/DD/YYYY)

6. Individual or Joint/Group Filing (Check Applicable Line)

_ X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	264415	D
Common Stock	85765	I	By Spouse

*Table II - Derivative Securities Beneficially Owned ( e.g.* , puts, calls, warrants, options, convertible securities)**
1. Title of Derivate Security (Instr. 4)	2. Date Exercisable and Expiration Date (MM/DD/YYYY)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivate Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security		6. Nature of Indirect Beneficial Ownership (Instr. 5)
Stock Option (right to buy)	⁽¹⁾	8/14/2022	Common Stock	4687	$1.8800	D
Stock Option (right to buy)	⁽²⁾	3/18/2023	Common Stock	1353	$2.3600	D
Stock Option (right to buy)	⁽³⁾	2/17/2024	Common Stock	18000	$9.7800	D
Stock Option (right to buy)	⁽⁴⁾	3/15/2025	Common Stock	14700	$4.4100	D
Stock Option (right to buy)	⁽⁵⁾	3/14/2026	Common Stock	14100	$2.9700	D
Stock Option (right to buy)	⁽⁶⁾	3/14/2027	Common Stock	21000	$1.0200	D
Stock Option (right to buy)	⁽⁷⁾	6/14/2027	Common Stock	56000	$0.8700	D

Explanation of Responses:
(1)	The stock option was granted on 8/15/2012. The option vests over four years with 1/4 of the total number of shares subject to the option vesting on the first anniversary of the date of grant and 1/48th of the total number of shares subject to the option vesting monthly thereafter, until fully vested on 8/15/2016.
(2)	The stock option was granted on 3/19/2013. The option vests over four years with 1/4 of the total number of shares subject to the option vesting on the first anniversary of the date of grant and 1/48th of the total number of shares subject to the option vesting monthly thereafter, until fully vested on 3/19/2017.
(3)	The stock option was granted on 2/18/2014. The option vests over four years with 1/4 of the total number of shares subject to the option vesting on the first anniversary of the date of grant and 1/48th of the total number of shares subject to the option vesting monthly thereafter, until fully vested on 2/18/2018.
(4)	The stock option was granted on 3/16/2015. The option vests over four years with 1/4 of the total number of shares subject to the option vesting on the first anniversary of the date of grant and 1/48th of the total number of shares subject to the option vesting monthly thereafter, until fully vested on 3/16/2019.
(5)	The stock option was granted on 3/15/2016. The option vests over four years with 1/4 of the total number of shares subject to the option vesting on the first anniversary of the date of grant and 1/48th of the total number of shares subject to the option vesting monthly thereafter, until fully vested on 3/15/2020.
(6)	The stock option was granted on 3/15/2017. The option vests over four years with 1/4 of the total number of shares subject to the option vesting on the first anniversary of the date of grant and 1/48th of the total number of shares subject to the option vesting monthly thereafter, until fully vested on 3/15/2021.
(7)	The stock option was granted on 6/15/2017. The option vests over four years with 1/4 of the total number of shares subject to the option vesting on the first anniversary of the date of grant and 1/48th of the total number of shares subject to the option vesting monthly thereafter, until fully vested on 6/15/2021.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
Humphrey David Carl 4767 NEXUS CENTRE DR. SAN DIEGO, CA 92121			Vice President, Finance

Signatures
/s/ David C. Humphrey		6/9/2017
^** Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:	File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.