LONDON, May 4, 2017 /PRNewswire/ -- Smith & Nephew (LSE:SN, NYSE:SNN), the global medical technology business, welcomes the publication of a new research paper showing how pressure ulcers, when treated with Collagenase SANTYL Ointment, achieve faster rates of granulation and epithelialization when compared against medicinal honey treatment. Granulation is the process in which new connective tissue and capillaries form around the edges of a wound while epithelialization is the regrowth of skin over an open wound.

Collagenase SANTYL® Ointment

In a retrospective study of 787 patients, those who received SANTYL treatment on 1034 pressure ulcers were 38% more likely to achieve 100% granulation, and 47% more likely to achieve epithelialization at one year when compared to medicinal honey treatment.

In addition, those patients treated with SANTYL had significantly fewer hospital outpatient visits (9.1 "vs." 12.6; p<0.001), fewer total selective sharp debridements (2.7 "vs." 4.4; p<0.001), and fewer pressure ulcers requiring NPWT (29% "vs.' 38%; p=0.002). 

The retrospective database analysis was conducted on deidentified hospital outpatient wound clinic electronic health records from 2007 to 2013 extracted from the US Wound Registry, and published in the journal Advances in Wound Care.  Gilligan, A.M., et al. Comparative effectiveness of Clostridial Collagenase Ointment to medicinal honey for treatment of pressure ulcers. Volume 6, Number 4 (April 2017).

Collagenase SANTYL Ointment is the only FDA-approved enzymatic debrider. SANTYL actively and selectively removes necrotic tissue without harming granulation tissue. SANTYL is indicated for debriding chronic dermal ulcers and severely burned areas. SANTYL is a topical biologic agent that has a unique mechanism of action and has been shown in other studies to help reduce the overall cost of treating chronic wounds. Use of SANTYL should be terminated when debridement of necrotic tissue is complete and granulation tissue is established. SANTYL is supported by years of multiple clinical trials that have underscored its efficacy. These clinical studies support the use of SANTYL Ointment as a first-line debridement both in between weekly sharp debridements and as a stand-alone product.

"This research adds to the body of knowledge of the effectiveness of SANTYL in a myriad of topical interventions available to wound management clinicians," said Cathy Milne, APRN, MSN, BC, CWOCN of Connecticut Clinical Nursing Associates. "Gilligan's work underscores the importance of granulation and epithelialization in advancing pressure ulcers through the healing process."           

"Pressure ulcers are a significant burden to patients and the healthcare system," said Andy Weymann, MD, Chief Medical Officer at Smith & Nephew. "We are committed to reduce the financial and emotional costs of living with pressure ulcers and this new research, using real-world, electronic health record data, demonstrates SANTYL is the better choice for helping patients with pressure ulcers."

About Smith & Nephew
Smith & Nephew is a global medical technology business dedicated to helping healthcare professionals improve people's lives. With leadership positions in Orthopaedic Reconstruction, Advanced Wound Management, Sports Medicine and Trauma & Extremities, Smith & Nephew has around 15,000 employees and a presence in more than 100 countries. Annual sales in 2015 were more than $4.6 billion. Smith & Nephew is a member of the FTSE100 (LSE:SN, NYSE:SNN).

For more information about Smith & Nephew, please visit our website www.smith-nephew.com, follow @SmithNephewplc on Twitter or visit SmithNephewplc on Facebook.com.

Forward-looking Statements
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©2017 Smith & Nephew, All rights reserved.
SANTYL is a registered trademark of Smith & Nephew.

Smith & Nephew logo. (PRNewsFoto/Smith & Nephew)

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SOURCE Smith & Nephew

Copyright 2017 PR Newswire

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