UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

Under the Securities Exchange Act of 1934
(Amendment No.____)*

WINDTREE THERAPEUTICS INC.
(Name of Issuer)

Common Stock, $0.001 Par Value Per Share
(Title of Class Securities)

97382D105
(CUSIP Number)

December 31, 2016
(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:**
[x] Rule 13d-1(b)
[ ] Rule 13d-1(c)
[ ] Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosure provided in a prior cover page.

** Nathan Fischel, Fariba Ghodsian and DAFNA Capital Management, LLC are filing this Schedule 13G pursuant to Rule 13d-1(b).

The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.

CUSIP No. 97382D105

1.NAME OF REPORTING PERSONS.
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY).

DAFNA Capital Management, LLC
36-4334068

2.CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)

(A)  [ ]
(B)  [ ]

3.SEC USE ONLY


4.CITIZENSHIP OR PLACE OF ORGANIZATION

Delaware


NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5.SOLE VOTING POWER

208,333

6.SHARED VOTING POWER

0

7.SOLE DISPOSITIVE POWER

208,333

8.SHARED DISPOSITIVE POWER

0

9.AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

208,333

10.CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(SEE INSTRUCTIONS)


11.PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

2.40%

12.TYPE  OF REPORTING PERSON (SEE INSTRUCTIONS)

IA


CUSIP No.  97382D105


1.NAME OF REPORTING PERSONS.
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY).

Nathan Fischel


2.CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)

(A)  [ ]
(B)  [ ]

3.SEC USE ONLY


4.CITIZENSHIP OR PLACE OF ORGANIZATION

Austria citizen (U.S. permanent resident)



NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH


5.SOLE VOTING POWER

208,333

6.SHARED VOTING POWER

0

7.SOLE DISPOSITIVE POWER

208,333

8.SHARED DISPOSITIVE POWER

0

9.AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

208,333

10.CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(SEE INSTRUCTIONS)


11.PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

2.40%

12.TYPE  OF REPORTING PERSON (SEE INSTRUCTIONS)

IN, HC


CUSIP No.  97382D105


1.NAME OF REPORTING PERSONS.
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY).

Fariba Ghodsian


2.CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)

(A)  [ ]
(B)  [ ]

3.SEC USE ONLY


4.CITIZENSHIP OR PLACE OF ORGANIZATION

United States of America


NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH


5.SOLE VOTING POWER

208,333

6.SHARED VOTING POWER

0

7.SOLE DISPOSITIVE POWER

208,333

8.SHARED DISPOSITIVE POWER

0

9.AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

208,333

10.CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(SEE INSTRUCTIONS)


11.PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

2.40%

12.TYPE  OF REPORTING PERSON (SEE INSTRUCTIONS)

IN, HC

Item 1.
        (a)     Name of Issuer
                Windtree Therapeutics, Inc.
        (b)     Address of Issuer's Principal Executive Offices
                2600 Kelly Road, Suite 100, Warrington, Pensylvania 18976-3622

Item 2.
        (a)     Name of Person Filing
                This Schedule 13G is being filed on behalf of DAFNA
                Capital Management, LLC, Nathan Fischel and Fariba
                Ghodsian (each, a "Reporting Person").
        (b)     Address of Principal Business office or, if None,
                Residence For each Reporting Person,
                10990 Wilshire Boulevard, Suite 1400
                Los Angeles, CA 90024
        (c)     Citizenship
                DAFNA Capital Management, LLC is a Delaware limited
                liability company.
                Dr. Fischel is a citizen of Austria and a U.S.
                permanent resident.
                Dr. Ghodsian is a citizen of the United States.
        (d)     Title of Class of Securities
                Common Stock
        (e)     CUSIP Number
                97382D105

Item 3. If this statement is filed pursuant to ss. 240.13d-1(b), or
        240.13d-2(b) or (c), check whether the person filing is a:
        (a) [ ] Broker or dealer registered under section 15 of the Act
                (15 U.S.C. 78c).
        (b) [ ] Bank as defined in section 3(a)(6) of the Act
                (15 U.S.C. 78c).
        (c) [ ] Insurance company as defined in section 3(a)(19) of the
                 Act (15 U.S.C. 78c).
        (d) [ ] Investment company registered under section 8 of the
                Investment Company Act (15 U.S.C. 80a-8).
        (e) [x] An investment adviser in accordance with
                ss. 240.13d-1(b)(1)(ii)(E).*
        (f) [ ] An employee benefit plan or endowment fund in accordance
                with ss. 240.13d-1(b)(ii)(F).
        (g) [x] A parent holding company or control person in accordance
                with ss. 240.13d-1(b)(1)(ii)(G).**
        (h) [ ] A savings association as defined in Section 3(b) of the
                Federal Deposit Insurance Act (12 U.S.C. 1813).
        (i) [ ] A church plan that is excluded from the definition of an
                investment company under section 3(c)(14) of the
                Investment Company Act of 1940 (15 U.S.C. 80a 3).
        (j) [ ] Group in accordance with ss. 240.13d-1(b)(ii)(J).
        * DAFNA Capital Management, LLC is an investment adviser in
        accordance with ss. 240.13d-1(b)(1)(ii)(E).
        ** Drs. Fischel and Ghodsian are control persons of DAFNA
        Capital Management, LLC in accordance with
        ss. 240.13d-1(b)(1)(ii)(G).

Item 4. Ownership
        For each Reporting Person:
        (a) Amount beneficially owned: 208,333 (the "Shares")
        (b) Percent of class: 2.40%*
        (c) Number of shares to which the Reporting Person has:
        (i)  Sole power to vote or to direct the vote: 208,333
        (ii) Shared power to direct the vote: 0
        (iii) Sole power to dispose or to direct the disposition
        of: 208,333
        (iv) Shared power to dispose or to direct the disposition
        of: 0.

        *The ownership percentage is calculated based on 8,476,033
        shares of Common Stock outstanding as of November 7, 2016,
        as reported in the issuer's most recent Quarterly Report on
        Form 10-Q for the quarterly period ended September 30, 2016,
        as filed with the Securities and Exchange Commission on
        November 14, 2016 plus the 208,333 shares of Common Stock
        relating to the warrants held by the Reporting Persons assuming
        full exercise of such warrants.

Item 5. Ownership of Five Percent or Less of a Class.
        If this statement is being filed to report the fact that as of
        the date hereof the reporting person has ceased to be the
        beneficial owner of more than five percent of the class
        securities, check the following [x]

Item 6. Ownership of More than Five Percent on Behalf of Another Person.
        N/A

Item 7. Identification and Classification of the Subsidiary Which
        Acquired the Security Being Reported on By the Parent Holding
        Company.
        N/A

Item 8. Identification and Classification of Members of the Group.
        N/A

Item 9. Notice of Dissolution of Group.
        N/A

Item 10.Certification:
        By signing below, I certify that, to the best of my knowledge
        and belief, the securities referred to above were not acquired
        and are not held for the purpose or with the effect of changing
        or influencing the control of the issuer and were not acquired
        and are not held in connection with or as a participant in any
        transaction having that purpose or effect.


SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true,
complete and correct.

Date:  February 13, 2017

        DAFNA Capital Management, LLC
        By: /s/ Nathan Fischel
        Nathan Fischel,MD, CFA, CEO

        /s/ Nathan Fischel
        Nathan Fischel, MD, CFA

        /s/ Fariba Ghodsian
        Fariba Ghodsian, Ph.D., MBA



Exhibit A

Joint Filing Agreement Pursuant to Rule 13d-1

This agreement is made pursuant to Rule 13d-l(k)(1) under the Securities
and Exchange Act of 1934, as amended (the "Act") by and among the parties
listed below, each referenced to herein as a "Joint Filer". The Joint
Filers agree that a statement of beneficial ownership as required by
Sections 13(g) or 13(d) of the Act and the Rules thereunder may be filed
on each of their behalf on Schedule 13G or Schedule 13D, as appropriate,
and that said joint filing may thereafter be amended by further joint
filings.  The Joint Filers state that they each satisfy the requirements
for making a joint filing under Rule 13d-1.

Date:  February 13, 2017

        DAFNA Capital Management, LLC
        By: /s/ Nathan Fischel
        Nathan Fischel, MD, CFA, CEO

        /s/ Nathan Fischel
        Nathan Fischel, MD, CFA

        /s/ Fariba Ghodsian
        Fariba Ghodsian, Ph. D. MBA