FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Kent Richard S 		2. Issuer Name and Ticker or Trading Symbol

CEMPRA, INC. [ CEMP ] 		5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__ X __ Director                      _____ 10% Owner
_____ Officer (give title below)      _____ Other (specify below)
(Last)          (First)          (Middle)

C/O INTERSOUTH PARTNERS, 102 CITY HALL PLAZA, SUITE 200 		3. Date of Earliest Transaction (MM/DD/YYYY)

3/4/2015
(Street)

DURHAM, NC 27701
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
6. Individual or Joint/Group Filing (Check Applicable Line)

_ X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock                  392   D    
Common Stock   3/4/2015     M    15000   A $13.10   15392   D    

Table II - Derivative Securities Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3) 		2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8) 		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4) 		8. Price of Derivative Security
(Instr. 5) 		9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (Right to Buy)   $13.10   3/4/2015     M      15000         (1) 1/7/2024   Common Stock   15000   $0.00   0   D    
Stock Option (Right to Buy)   $7.62                      (2) 3/19/2022   Common Stock   15000     15000   D   (3)  
Stock Option (Right to Buy)   $6.79                      (4) 2/3/2023   Common Stock   15000     15000   D   (3)  
Stock Option (Right to Buy)   $23.51                      (5) 12/31/2024   Common Stock   15000     15000   D    
Stock Option (Right to Buy)   $31.13                      (6) 12/31/2025   Common Stock   15000     15000   D    

Explanation of Responses:
( 1)  The option vests according to the following schedule: 1/12th of the shares vest monthly at the end of each month over 12 months, beginning after 01/01/2014.
( 2)  The option vests according to the following schedule: 1/12th of the shares vest at the end of each month, beginning 03/31/12.
( 3)  These stock options are held by Dr. Kent for the benefit of InterSouth Partners. Dr. Kent disclaims beneficial ownership of these securities and this report is not an admission that he is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his pecuniary interest therein.
( 4)  The option vests according to the following schedule: 1/12th of the shares vest at the end of each month, beginning 01/31/13.
( 5)  The option vests on the following schedule: 1/12th of the shares vest monthly at the end of each month over 12 months, beginning after 01/01/2015.
( 6)  The option vests on the following schedule: 1/12th of the shares vest monthly at the end of each month over 12 months, beginning after 01/01/2016.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
Kent Richard S
C/O INTERSOUTH PARTNERS
102 CITY HALL PLAZA, SUITE 200
DURHAM, NC 27701 		X



Signatures
/s/ Alexander M. Donaldson, by Power of Attorney 10/20/2016
** Signature of Reporting Person Date


Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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