Law Offices of Howard G. Smith announces an investigation on behalf of investors of Osiris Therapeutics, Inc. (“Osiris” or the “Company”) (NASDAQ: OSIR) concerning the Company and its officers’ possible violations of federal securities laws.

On May 27, 2016, after the market closed, the Company announced that it was advised by the United States Attorney’s Office for the Southern District of New York that the office had opened a criminal investigation into the Company. Osiris also announced that it understands the investigation to relate to previously disclosed matters also under investigation by the SEC.

On this news, shares of Osiris fell approximately 10% during intra-day trading on May 31, 2016, on unusually heavy trading volume, thereby injuring investors.

If you purchased Osiris securities, have information or would like to learn more about these claims, or have any questions concerning this announcement or your rights or interests with respect to these matters, please contact Howard G. Smith, Esquire, of Law Offices of Howard G. Smith, 3070 Bristol Pike, Suite 112, Bensalem, Pennsylvania 19020 by telephone at (215) 638-4847, toll-free at (888) 638-4847, or by email to howardsmith@howardsmithlaw.com, or visit our website at http://www.howardsmithlaw.com.

This press release may be considered Attorney Advertising in some jurisdictions under the applicable law and ethical rules.

Law Offices of Howard G. SmithHoward G. Smith, Esquire215-638-4847888-638-4847howardsmith@howardsmithlaw.comwww.howardsmithlaw.com

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