By Tess Stynes 

Shire PLC said Tuesday that it has offered to acquire Baxalta Inc. in a stock deal valued at roughly $30.6 billion, in a combination what would create a leader in treatments for rare diseases.

Under the proposed deal, Baxalta holders would receive 0.1687 Shire American depositary share for each Baxalta share held, implying a value of $45.23 per Baxalta share and a premium of 36% based on Monday's closing prices.

Baxalta shares rose 27% to $42.10 in recent premarket trading, while Shire's ADRs were halted.

A Baxalta spokesman wasn't immediately available to comment.

The offer comes just more than a month after Baxalta, which sells treatments for rare bleeding disorders and immune deficiencies, completed its spinoff from Baxter International Inc. Baxter remains Baxalta's biggest shareholder, with a stake of about 24%, according to FactSet.

In 2014, Baxalta had net sales of $6 billion and net income from continuing operations of $1.2 billion.

Write to Tess Stynes at tess.stynes@wsj.com

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