By Laura Stevens 

United Parcel Service Inc. said it succeeded in raising prices for e-commerce packages, while at the same time growing the business, in what may be the beginning to a solution to one of its biggest challenges: making e-commerce more profitable.

The Atlanta-based delivery giant said it did this in part by changing the way it charges for ground packages, pricing them by box size instead of solely by weight, in an effort to get e-tailers to either use smaller boxes or pay up for the space. The company also declined to renew contracts with "a couple of substantial customers" whose business wasn't profitable enough for UPS, Chief Financial Officer Kurt Kuehn said in an interview. He declined to identify them.

In addition, UPS raised prices across the board and increased fuel surcharges. Improving e-commerce profitability "is a big priority for us, and it's a combination of product design, improved convenience, reduced costs and some revenue management," Mr. Kuehn said.

Revenues for U.S. ground packages grew 5.3% to $6.36 billion in the first quarter. That helped buoy total U.S. domestic package operating profit, which rose 10.5% to $1.02 billion.

Regarding the box size price increase, "It's not our goal to just increase costs to customers. It's to have a win-win where they reduce their materials, expense, and we get to reduce our operating expense," Mr. Kuehn said. He said the revenue growth from that pricing change will level out over time.

The results were good news for UPS, which has struggled with inherently less profitable e-commerce deliveries as the company delivers single, lightweight packages to houses scattered throughout a neighborhood. UPS said Tuesday it's increasing the number of Access Point locations--retailers who will accept deliveries of a package for customers to pick up to more than 20,000 this year, including adding locations in San Francisco, Washington, D.C., and Boston. Those save it money because it can deliver multiple packages to just one stop.

UPS is also continuing its rollout of Orion, a proprietary routing system designed to shave miles off drivers' routes, aiming for 70% of its U.S. drivers to use the system by the end of the year.

Also during the quarter, UPS experienced higher growth in business-to-business shipments as UPS targeted the health care, tech and industrial sectors and benefited from shifting trade patterns as manufacturers increasingly skip the middleman and ship directly to businesses.

"We are seeing more and more industrial and manufacturers actually going direct to businesses, so there is some change in the flow of goods even within the internet commerce," Mr. Kuehn added. In the long-term, though, he said business-to-consumer shipments will grow the fastest.

UPS also touted big European growth in the wake of FedEx Corp.'s announcement it would acquire Dutch package-delivery company TNT Express NV this month for $4.8 billion. The move was an end run around UPS, which was blocked by regulators from acquiring TNT in 2013 but laid much of the ground work for the deal.

UPS executives say they've moved on, but cautioned FedEx will face similar scrutiny.

"I will just remind everyone that the FedEx/TNT deal--that is a complex deal and we expect that regulatory agencies will be as stringent on this deal as they have been on previous deals," said Chief Executive David Abney.

UPS is investing almost $2 billion over five years as volume growth in Europe takes off, executives said. European export average daily volume has more than doubled over the past decade, they added, and the company is moving to add more capacity in the market.

International gains were "driven by impressive growth in Europe, up more than 9%, and we expect strong volume growth there to continue," added Mr. Kuehn. Operating profit in the company's international package business increased nearly 14% to $498 million, even as revenues fell 5% due to currency effects.

The company said it's hedged both its exposure to the euro and the British pound for the next couple of years, which should keep results stable.

The full-year outlook remains unchanged, with expected per-share earnings of between $5.05 and $5.30. U.S. package volume is expected to grow about 3%, with revenues growing at a slightly faster pace.

Shares were up 3% in recent midday trading at $100.59.

UPS posted earnings of $1.03 billion, or $1.12 per share, up from $911 million, or 98 cents a share, a year earlier. Revenue grew 1.4% to $13.98 billion. Analysts had expected earnings of $1.09 on revenue of $14.27 billion, according to Thomson Reuters.

The company's supply chain and freight division's operating profit rose 2% to $151 million.

Separately, the company said that Mr. Kuehn was retiring after nearly 38 years with UPS and would be replaced by Richard Peretz, currently corporate controller and treasurer.

Mr. Kuehn, who has held the title of CFO for eight years, was the company's first investor relations officer following UPS's 1999 initial public offering. He started with UPS as a driver while still in college.

Incoming CFO Mr. Peretz started as a customer service representative with UPS during college and has held a number of internal leadership positions related to finance.

Write to Laura Stevens at laura.stevens@wsj.com

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