By David Benoit 

Less than three weeks before of one of the largest proxy votes in history, activist Nelson Peltz received an important recommendation saying he deserves a seat on the board of DuPont Co.

Institutional Shareholder Services Inc. said Monday that DuPont shareholders should elect Mr. Peltz and John Myers, two of the four nominees Mr. Peltz's Trian Fund Management LP has put forward in an increasingly bitter fight for shareholder votes.

The sides have traded barbs for months about whether Mr. Peltz, 72 years old, deserves a seat on the chemicals giant's board.

Trian says Mr. Peltz will help ensure the company delivers results after failing to live up to its promises. DuPont has opened its doors to a Trian-nominated representative on its board, but not to Mr. Peltz, saying he would be fixated on creating a "shadow management team" to drive a dramatic breakup the board has already rejected.

ISS, whose opinions can help sway some shareholders, said overall having Mr. Peltz on the board would be a positive for DuPont. "The real risk seems less that one wily shareholder nominee outfoxes eight incumbents than that the right issues are never fully aired."

DuPont shares rose 4.6%, one of their biggest percentage gains in the past two years, giving Trian a new talking point. The activist has already said it was the catalyst for some of the best days in DuPont stock in recent years and suggested that the possibility it would lose the proxy vote was one reason for a recent stock slump. DuPont says the stock's long-term, market-beating returns are a validation of its strategy.

DuPont on Monday said ISS reached the "wrong conclusion" and that the opinion was "ignoring the success of our transformative strategy and the value-destructive nature of Trian's breakup agenda." The company defended its current board as having the "right mix of experience and skills" and reiterated its concern that what it called Trian's "shadow management team" could harm the company.

The opinion was a victory for the New York investment fund even though ISS backed only half of its nominees. Last year, Trian privately asked for a single seat on the board. But after DuPont was steadfast in refusing to take a Trian principal, the activist launched its proxy fight for four seats.

Since September, DuPont and Trian have waged a public battle over DuPont's future. The fight is scheduled to come to a head next month in Wilmington, Del., when shareholders are set to vote on the board nominees. The fight could still settle before the May 13 vote.

ISS, the largest proxy adviser, can influence how institutional shareholders such as mutual funds vote, though its recommendation isn't seen as insurmountable to the losing side. ISS bases its decisions in such situations on two questions: whether an activist has made the case that change is warranted; and, if yes, whether or not the dissident is better placed than the current board to drive such change.

The vote is anticipated to be particularly close at DuPont, whose $65 billion market capitalization makes it one of the largest companies to face such a campaign. Both sides are aggressively canvassing shareholders across the country, meeting with portfolio managers at large shareholders individually and with some smaller professional investors in group meetings.

To decide on their vote, major institutional shareholders typically use internal voting committees, which some say reduces ISS's impact though the shareholders' committees still take ISS's views into account. Indeed, some high-profile campaigns have seen companies beat back a negative ISS recommendation.

"ISS is not outcome determinative in election contests, as most large institutional investors will make independent decisions in such situations," said Jordan Kovler, of proxy solicitor D.F. King & Co. "While there are certain quantitative and smaller institutional investors that unfortunately outsource the process to ISS, the decisions made by the largest holders will sway the final vote."

Still, winning ISS's backing can provide a boost, and the proxy adviser seconded many of Trian's most important arguments, particularly that performance has been disappointing and that the management lacks credibility with shareholders.

"This is not a broken company--but there is compelling evidence that the dissidents are onto something in their critique," ISS wrote. "Operating efficiency is not what it should be, yet instead of addressing the core issues, the board and management, at least in their communications with shareholders, are more inclined to obfuscation than accountability."

Along with Mr. Peltz, ISS advocated the election of Mr. Myers citing his background running General Electric Co.'s asset-management business. DuPont had at one point offered to take Mr. Myers onto the board.

On the issue of whether DuPont should be broken into different pieces, ISS said it couldn't make a recommendation, but sided with Trian in saying it should be reviewed.

"There seems little reason to believe a robust, fact-based boardroom discussion of this topic, as well, would somehow not be in the best interest of shareholders," ISS wrote.

Write to David Benoit at david.benoit@wsj.com

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