By Julie Jargon And Chelsey Dulaney 

McDonald's Corp. posted its steepest monthly decline in U.S. same-store sales in more than 14 years, adding urgency to the burger giant's efforts to rejuvenate its business in its most important market.

McDonald's reported sharper-than-expected sales declines in all its divisions in November. The U.S. slide was the largest, with sales falling 4.6% from the same month a year ago, far more than the 1.9% drop analysts had projected and more than September's 4.1% sales slide in what was then the company's biggest monthly drop since early 2003.

McDonald's blamed the decline on "strong competitive activity" and said it is "diligently working to enhance its marketing, simplify the menu, and implement a more locally driven organizational structure to increase relevance with consumers."

The company has been losing customers to fast-casual chains and to such rivals as Five Guys Holdings LLC and Chick-fil-A Inc. that focus on just a few menu items. McDonald's menu has become bloated in recent years as the chain has added everything from fruit smoothies to salads in a bid to appeal to a broad range of customers. The result has been slower service, which has driven away many customers.

McDonald's Chief Executive Don Thompson has vowed to fix the problems and the company said it would host an investor conference on Wednesday, presumably to update investors on its plans. McDonald's also has shuffled its management ranks, naming a new U.S. president in August and, more recently, creating a new organizational structure in the U.S. with four geographic zones to better respond to local tastes. Under that system, for example, menu items that might appeal to customers in the South won't necessarily be offered to those in the West.

"The reality is that our current U.S. structure is not optimized for the customer," McDonald's U.S.A. President Mike Andres said in an October email to U.S. franchisees and corporate staff, which was reviewed by The Wall Street Journal. "What has worked for McDonald's U.S. for the past decade is not sufficient to propel the business forward in the future."

McDonald's shares, which were already down slightly for the year, dropped by more than 3% in Monday morning trading after the latest sales report.

The company said global same-store sales fell 2.2% in November, while analysts had expected a 1.7% decline, according to Consensus Metrix. November's drop-off followed a smaller-than-expected 0.5% slide in October.

In the company's Asia-Pacific, Middle East and Africa region, sales at existing locations fell 4%, missing the 3.8% drop analysts were expecting. McDonald's performance in the region appears to be improving somewhat after one of its meat suppliers was accused of intentionally selling expired meat to restaurants in July. The scandal shook consumer confidence and has driven down sales in recent months. McDonald's said it expects the supplier issue and currency fluctuations to bring down its fourth-quarter results.

In Europe, broader economic softness has been compounded by political complications in Russia, where authorities have been inspecting and shutting McDonald's restaurants--widely seen as retaliation for U.S. sanctions in response to Russia's military incursion in Ukraine. McDonald's sales fell 2% in its Europe division in November as "very weak results" in Russia offset strength in the U.K. Analysts had projected a 1.9% decline in the region.

McDonald's projected the supplier issue in China would dent its fourth-quarter earnings by between seven and 10 cents a share, while the strengthening of the U.S. dollar against foreign currencies is expected to bring down results by between seven and nine cents a share.

Analysts polled by Thomson Reuters recently said they expected per-share earnings to fall 9% to $1.27 a share in the fourth quarter. Revenue is expected to fall 3% to $6.85 billion.

Write to Julie Jargon at julie.jargon@wsj.com and Chelsey Dulaney at Chelsey.Dulaney@wsj.com

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