Initial Statement of Beneficial Ownership (3)

FORM 3	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0104 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^*

5AM Partners III, LLC

2. Date of Event Requiring Statement (MM/DD/YYYY) 7/15/2014

3. Issuer Name and Ticker or Trading Symbol

EPIRUS Biopharmaceuticals, Inc. [EPRS]

(Last) (First) (Middle)

2200 SANDHILL ROAD, STE 110

4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director ___ X ___ 10% Owner
_____ Officer (give title below) _____ Other (specify below)

(Street)

MENLO PARK, CA 94025

(City) (State) (Zip)

5. If Amendment, Date Original Filed (MM/DD/YYYY)

6. Individual or Joint/Group Filing (Check Applicable Line)

___ Form filed by One Reporting Person
_ X _ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	55649	I	Footnote (1)(2) ⁽¹⁾ ⁽²⁾
Common Stock	2159261	I	Footnote (2)(3) ⁽²⁾ ⁽³⁾

*Table II - Derivative Securities Beneficially Owned ( e.g.* , puts, calls, warrants, options, convertible securities)**
1. Title of Derivate Security (Instr. 4)	2. Date Exercisable and Expiration Date (MM/DD/YYYY)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivate Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security		6. Nature of Indirect Beneficial Ownership (Instr. 5)
Warrants to Purchase Common Stock	7/15/2014	4/3/2019	Common Stock	511	$7.60	I	Footnote (1)(2) ⁽¹⁾ ⁽²⁾
Warrants to Purchase Common Stock	7/15/2014	4/3/2019	Common Stock	19834	$7.60	I	Footnote (2)(3) ⁽²⁾ ⁽³⁾

Explanation of Responses:
( 1)	Shares directly beneficially owned by 5AM Co-Investors III, L.P.
( 2)	5AM Partners III, LLC is the general partner of 5AM Ventures III, L.P. and 5AM Co-Investors III, L.P. Dr. John Diekman, Andrew Schwab and Dr. Scott Rocklage are the managing members of 5AM Partners III. 5AM Partners III, LLC may be deemed to have sole voting and investment power over the shares beneficially owned by 5AM Ventures III, L.P. and 5AM Co-Investors III, L.P. Dr. Diekman, Mr. Schwab and Dr. Rocklage may be deemed to have shared voting and investment power over the shares beneficially owned by 5AM Ventures III, L.P. and 5AM Co-Investors III, L.P. Each of 5AM Partners III, LLC, Dr. Diekman, Mr. Schwab and Dr. Rocklage disclaim beneficial ownership of such shares, except to the extent of its pecuniary interest therein.
( 3)	Shares directly beneficially owned by 5AM Ventures III, L.P.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
5AM Partners III, LLC 2200 SANDHILL ROAD STE 110 MENLO PARK, CA 94025		X
5AM VENTURES III, L.P. 2200 SAND HILL ROAD, SUITE 110 MENLO PARK, CA 94025		X
5AM Co-Investors III, L.P. 2200 SAND HILL ROAD, SUITE 110 MENLO PARK, CA 94025		X
Schwab Andrew J. 2200 SANDHILL RD, STE 110 MENLO PARK, CA 94025		X
DIEKMAN JOHN D 2200 SANDHILL RD, STE 110 MENLO PARK, CA 94025		X

Signatures
Scott Rocklage, Managing Member of 5AM Partners III, LLC		7/24/2014
^** Signature of Reporting Person		Date
Scott Rocklage, Managing Member of 5AM Partners III, LLC, the general partner of 5AM Ventures III, L.P.		7/24/2014
^** Signature of Reporting Person		Date
Scott Rocklage, Managing Member of 5AM Partners III, LLC, the general partner of 5AM Co-Investors III, L.P.		7/24/2014
^** Signature of Reporting Person		Date
Dr. John D. Diekman		7/24/2014
^** Signature of Reporting Person		Date
Andrew Schwab		7/24/2014
^** Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:	File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.