CUSIP NO. 576314108 13G Page
1 of 14
UNITED STATES
SECURITIES AND EXCHANGE
COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
Under the Securities Exchange Act
of 1934
(Amendment No. 1)*
MAST THERAPEUTICS, INC.
(Name of Issuer)
Common Stock, par value $0.001
per share
(Title of Class of Securities)
576314108
(CUSIP Number)
December 31, 2013
(Date of Event Which Requires
Filing of this Statement)
Check the appropriate box to
designate the rule pursuant to which this Schedule is
filed:
[X] Rule 13d‑1(b)
[ ] Rule 13d‑1(c)
[ ] Rule 13d‑1(d)
*The remainder of this cover page
shall be filled out for a reporting person's
initial filing on this form with
respect to the subject class of securities, and
for any subsequent amendment
containing information which would alter the
disclosures provided in a prior
cover page.
The information required in the
remainder of this cover page shall not be deemed to
be "filed" for the
purpose of Section 18 of the Securities Exchange Act of 1934
("Act") or otherwise
subject to the liabilities of that section of the Act but
shall be subject to all other
provisions of the Act (however, see the Notes).
CUSIP NO. 576314108 13G Page
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1. NAMES OF REPORTING PERSONS.
Franklin Resources, Inc.
2. CHECK THE APPROPRIATE BOX
IF A MEMBER OF A GROUP
(a)
(b) X
3. SEC USE ONLY
4. CITIZENSHIP OR PLACE OF
ORGANIZATION
Delaware
NUMBER OF SHARES BENEFICIALLY
OWNED BY EACH REPORTING PERSON WITH:
5. SOLE VOTING POWER
(See Item 4)
6. SHARED VOTING POWER
(See Item 4)
7. SOLE DISPOSITIVE POWER
(See Item 4)
8. SHARED DISPOSITIVE POWER
(See Item 4)
9. AGGREGATE AMOUNT
BENEFICIALLY OWNED BY EACH REPORTING PERSON
12,046,100
10. CHECK IF THE AGGREGATE
AMOUNT IN ROW (9) EXCLUDES
CERTAIN SHARES [ ]
11. PERCENT OF CLASS
REPRESENTED BY AMOUNT IN ROW (9)
11.7%
12. TYPE OF REPORTING PERSON
HC, CO (See Item 4)
CUSIP NO. 576314108 13G Page
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1. NAMES OF REPORTING
PERSONS.
Charles B. Johnson
2. CHECK THE APPROPRIATE BOX
IF A MEMBER OF A GROUP
(a)
(b) X
3. SEC USE ONLY
4. CITIZENSHIP OR PLACE OF
ORGANIZATION
USA
NUMBER OF SHARES BENEFICIALLY
OWNED BY EACH REPORTING PERSON WITH:
5. SOLE VOTING POWER
(See Item 4)
6. SHARED VOTING POWER
(See Item 4)
7. SOLE DISPOSITIVE POWER
(See Item 4)
8. SHARED DISPOSITIVE POWER
(See Item 4)
9. AGGREGATE AMOUNT
BENEFICIALLY OWNED BY EACH REPORTING PERSON
12,046,100
10. CHECK IF THE AGGREGATE
AMOUNT IN ROW (9) EXCLUDES
CERTAIN SHARES [ ]
11. PERCENT OF CLASS
REPRESENTED BY AMOUNT IN ROW (9)
11.7%
12. TYPE OF REPORTING PERSON
HC, IN (See Item 4)
CUSIP NO. 576314108 13G Page
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1. NAMES OF REPORTING
PERSONS.
Rupert H. Johnson, Jr.
2. CHECK THE APPROPRIATE BOX
IF A MEMBER OF A GROUP
(a)
(b) X
3. SEC USE ONLY
4. CITIZENSHIP OR PLACE OF
ORGANIZATION
USA
NUMBER OF SHARES BENEFICIALLY
OWNED BY EACH REPORTING PERSON WITH:
5. SOLE VOTING POWER
(See Item 4)
6. SHARED VOTING POWER
(See Item 4)
7. SOLE DISPOSITIVE POWER
(See Item 4)
8. SHARED DISPOSITIVE POWER
(See Item 4)
9. AGGREGATE AMOUNT
BENEFICIALLY OWNED BY EACH REPORTING PERSON
12,046,100
10. CHECK IF THE AGGREGATE
AMOUNT IN ROW (9) EXCLUDES
CERTAIN SHARES [ ]
11. PERCENT OF CLASS
REPRESENTED BY AMOUNT IN ROW (9)
11.7%
12. TYPE OF REPORTING PERSON
HC, IN (See Item 4)
CUSIP NO. 576314108 13G Page
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1. NAMES OF REPORTING
PERSONS.
Franklin Advisers, Inc.
2. CHECK THE APPROPRIATE BOX
IF A MEMBER OF A GROUP
(a)
(b) X
3. SEC USE ONLY
4. CITIZENSHIP OR PLACE OF
ORGANIZATION
California
NUMBER OF SHARES BENEFICIALLY
OWNED BY EACH REPORTING PERSON WITH:
5. SOLE VOTING POWER
12,046,100
6. SHARED VOTING POWER
0
7. SOLE DISPOSITIVE POWER
12,046,100
8. SHARED DISPOSITIVE POWER
0
9. AGGREGATE AMOUNT
BENEFICIALLY OWNED BY EACH REPORTING PERSON
12,046,100
10. CHECK IF THE AGGREGATE
AMOUNT IN ROW (9) EXCLUDES
CERTAIN SHARES [ ]
11. PERCENT OF CLASS
REPRESENTED BY AMOUNT IN ROW (9)
11.7%
12. TYPE OF REPORTING PERSON
IA, CO (See Item 4)
CUSIP NO. 576314108 13G Page
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Item 1.
(a) Name of Issuer
MAST THERAPEUTICS, INC.
(b) Address of Issuer's
Principal Executive Offices
12390 El Camino Real, Suite 150
San Diego, CA 92130
Item 2.
(a) Name of Person Filing
(i): Franklin Resources, Inc.
(ii): Charles B. Johnson
(iii): Rupert H. Johnson, Jr.
(iv): Franklin Advisers, Inc.
(b) Address of Principal
Business Office or, if none, Residence
(i), (ii), and (iii):
One Franklin Parkway
San Mateo, CA 94403‑1906
(iv): One Franklin Parkway
San Mateo, CA 94403‑1906
(c) Citizenship
(i): Delaware
(ii) and (iii): USA
(iv): California
(d) Title of Class of Securities
Common Stock, par value $0.001
per share
(e) CUSIP Number
576314108
CUSIP NO. 576314108 13G Page
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Item 3. If this statement is
filed pursuant to §§240.13d‑1(b) or 240.13d‑2(b) or (c),
check whether the person filing
is a:
(a) [ ] Broker or dealer
registered under section 15 of the Act (15 U.S.C. 78o).
(b) [ ] Bank as defined in
section 3(a)(6) of the Act (15 U.S.C. 78c).
(c) [ ] Insurance company as
defined in section 3(a)(19) of the Act (15 U.S.C.
78c).
(d) [ ] Investment company
registered under section 8 of the Investment Company
Act of 1940 (15 U.S.C 80a‑8).
(e) [X] An investment adviser in
accordance with §240.13d‑1(b)(1)(ii)(E);
(f) [ ] An employee benefit plan
or endowment fund in accordance with
§240.13d‑1(b)(1)(ii)(F);
(g) [X] A parent holding company
or control person in accordance with
§240.13d‑1(b)(1)(ii)(G);
(h) [ ] A savings associations as
defined in Section 3(b) of the Federal Deposit
Insurance Act (12 U.S.C. 1813);
(i) [ ] A church plan that is excluded
from the definition of an investment
company under section 3(c)(14) of
the Investment Company Act of 1940 (15
U.S.C. 80a‑3);
(j) [ ] A non‑U.S.
institution in accordance with §240.13d‑1(b)(ii)(J);
(k) [ ] Group, in accordance with
§240.13d 1(b)(1)(ii)(K).
If filing as a non‑U.S.
institution in accordance with §240.13d‑1(b)(1)(ii) (J).
please specify the type of
institution:
Item 4. Ownership
The securities reported herein
are beneficially owned by one or more open‑ or closed‑end
investment companies or other
managed accounts that are investment management clients of
investment managers that are
direct and indirect subsidiaries (each, an “Investment
Management Subsidiary” and,
collectively, the “Investment Management Subsidiaries”) of
Franklin Resources Inc. (“FRI”),
including the Investment Management Subsidiaries listed
in this Item 4. When an
investment management contract (including a sub‑advisory
agreement) delegates to an
Investment Management Subsidiary investment discretion or
voting power over the securities
held in the investment advisory accounts that are
subject to that agreement, FRI
treats the Investment Management Subsidiary as having sole
investment discretion or voting
authority, as the case may be, unless the agreement
specifies otherwise. Accordingly,
each Investment Management Subsidiary reports on
Schedule 13G that it has sole
investment discretion and voting authority over the
securities covered by any such
investment management agreement, unless otherwise noted in
this Item 4. As a result, for
purposes of Rule 13d‑3 under the Act, the Investment
Management Subsidiaries listed in
this Item 4 may be deemed to be the beneficial owners
of the securities reported in
this Schedule 13G.
Beneficial ownership by
Investment Management Subsidiaries and other FRI affiliates is
being reported in conformity with
the guidelines articulated by the SEC staff in Release
No. 34‑39538 (January 12,
1998) relating to organizations, such as FRI, where related
entities exercise voting and
investment powers over the securities being reported
independently from each other.
The voting and investment powers held by Franklin Mutual
Advisers, LLC (“FMA”), an
indirect wholly‑owned Investment Management Subsidiary, are
exercised independently from FRI
and from all other Investment Management Subsidiaries
(FRI, its affiliates and the
Investment Management Subsidiaries other than FMA are
collectively, “FRI affiliates”).
Furthermore, internal policies and procedures of FMA and
FRI establish informational
barriers that prevent the flow between FMA and the FRI
affiliates of information that
relates to the voting and investment powers over the
securities owned by their
respective management clients. Consequently, FMA and FRI
affiliates report the securities
over which they hold investment and voting power
separately from each other for
purposes of Section 13 of the Act.
CUSIP NO. 576314108 13G Page
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Charles B. Johnson and Rupert H.
Johnson, Jr. (the “Principal Shareholders”) each own in
excess of 10% of the outstanding
common stock of FRI and are the principal stockholders
of FRI. FRI and the Principal
Shareholders may be deemed to be, for purposes of Rule
13d‑3 under the Act, the
beneficial owners of securities held by persons and entities for
whom or for which FRI
subsidiaries provide investment management services. The number of
shares that may be deemed to be
beneficially owned and the percentage of the class of
which such shares are a part are
reported in Items 9 and 11 of the cover pages for FRI
and each of the Principal
Shareholders. FRI, the Principal Shareholders and each of the
Investment Management
Subsidiaries disclaim any pecuniary interest in any of the such
securities. In addition, the
filing of this Schedule 13G on behalf of the Principal
Shareholders, FRI and the FRI
affiliates, as applicable, should not be construed as an
admission that any of them is,
and each of them disclaims that it is, the beneficial
owner, as defined in Rule 13d‑3,
of any of the securities reported in this Schedule 13G.
FRI, the Principal Shareholders, and each of the
Investment Management Subsidiaries
believe that they are not a
“group” within the meaning of Rule 13d‑5 under the Act and
that they are not otherwise
required to attribute to each other the beneficial ownership
of the securities held by any of
them or by any persons or entities for whom or for which
the Investment Management
Subsidiaries provide investment management services.
(a) Amount beneficially
owned:
12,046,100
(b) Percent of class:
11.7%
(c) Number of shares as to
which the person has:
(i) Sole power to vote or to
direct the vote
Franklin Resources, Inc.:
0
Charles B. Johnson:
0
Rupert H. Johnson, Jr.:
0
Franklin Advisers, Inc.:
12,046,100
(ii) Shared power to vote or to
direct the vote
0
(iii) Sole power to dispose or
to direct the disposition of
Franklin Resources, Inc.:
0
Charles B. Johnson:
0
Rupert H. Johnson, Jr.:
0
Franklin Advisers, Inc.:
12,046,100
(iv) Shared power to dispose or
to direct the disposition of
0
CUSIP NO. 576314108 13G Page
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Item 5. Ownership of Five
Percent or Less of a Class
If this statement is being filed
to report the fact that as of the date hereof
the reporting person has ceased
to be the beneficial owner of more than five
percent of the class of
securities,
check the following [ ]. Not
Applicable
Item 6. Ownership of More than Five
Percent on Behalf of Another Person
The clients of the Investment
Management Subsidiaries, including investment
companies registered under the
Investment Company Act of 1940 and other managed
accounts, have the right to
receive or power to direct the receipt of dividends
from, and the proceeds from the
sale of, the securities reported herein.
Franklin Biotechnology Discovery Fund, a series of
Franklin Strategic
Series, an investment company
registered under the Investment Company Act of
1940, has an interest in 5,453,500 shares, or 5.3%, and Franklin
Biotechnology Discovery Fund, a sub-fund of Franklin Templeton Investment Funds,
a Luxemburg registered SICAV has an interest 6,592,600 shares, or 6.4% of the
class of securities reported
herein.
Item 7. Identification and
Classification of the Subsidiary Which Acquired the Security
Being Reported on By the Parent
Holding Company
See Attached Exhibit C
Item 8. Identification and
Classification of Members of the Group
Not Applicable
Item 9. Notice of Dissolution of
Group
Not Applicable
CUSIP NO. 576314108 13G Page 10 of 14
Item 10. Certification
By signing below I certify that, to the best of my knowledge and belief, the securities
referred to above were acquired and are held in the ordinary course of business and were
not acquired and are not held for the purpose of or with the effect of changing or
influencing the control of the issuer of the securities and were not acquired and are not
held in connection with or as a participant in any transaction having that purpose or
effect.
This report shall not be construed as an admission by the persons filing the report that
they are the beneficial owner of any securities covered by this report.
Exhibits.
Exhibit A Joint Filing Agreement
Exhibit B Limited Powers of Attorney for Section 13 Reporting Obligations
Exhibit C Item 7 Identification and Classification of Subsidiaries
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify that the
information set forth in this statement is true, complete and correct.
Dated: February 3, 2014
Franklin Resources, Inc.
Charles B. Johnson
Rupert H. Johnson, Jr.
Franklin Advisers, Inc.
By: /s/MARIA GRAY
‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑
Maria Gray
Vice President and Secretary of Franklin Resources, Inc.
Attorney‑in‑Fact for Charles B. Johnson pursuant to Power of Attorney
attached to this Schedule 13G
Attorney‑in‑Fact for Rupert H. Johnson, Jr. pursuant to Power of Attorney
attached to this Schedule 13G
Secretary of Franklin Advisers, Inc.
Franklin Templeton Investment Funds on behalf of
Franklin Biotechnology Discovery Fund
By: /s/GREGORY E. MCGOWAN
‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑
Gregory E. McGowan
Director of Franklin Templeton Investment Funds
Franklin Strategic Series on behalf of
Franklin Biotechnology Discovery Fund
By: /s/LORI A
.
WEBER
‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑
Lori A. Weber
Vice President and Assistant Secretary of Franklin Strategic Series
CUSIP NO. 576314108 13G Page 11 of 14
EXHIBIT A
JOINT FILING AGREEMENT
In accordance with Rule 13d‑1(k) under the Securities Exchange Act of 1934, as amended,
the undersigned hereby agree to the joint filing with each other of the attached
statement on Schedule 13G and to all amendments to such statement and that such statement
and all amendments to such statement are made on behalf of each of them.
IN WITNESS WHEREOF, the undersigned have executed this agreement on February 3, 2014.
Franklin Resources, Inc.
Charles B. Johnson
Rupert H. Johnson, Jr.
Franklin Advisers, Inc.
By: /s/MARIA GRAY
‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑
Maria Gray
Vice President and Secretary of Franklin Resources, Inc.
Attorney‑in‑Fact for Charles B. Johnson pursuant to Power of Attorney
attached to this Schedule 13G
Attorney‑in‑Fact for Rupert H. Johnson, Jr. pursuant to Power of Attorney
attached to this Schedule 13G
Secretary of Franklin Advisers, Inc.
Franklin Templeton Investment Funds on behalf of
Franklin Biotechnology Discovery Fund
By: /s/GREGORY E. MCGOWAN
‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑
Gregory E. McGowan
Director of Franklin Templeton Investment Funds
Franklin Strategic Series on behalf of
Franklin Biotechnology Discovery Fund
By: /s/LORI A. WEBER
‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑
Lori A. Weber
Vice President and Assistant Secretary of Franklin Strategic Series
CUSIP NO. 576314108 13G Page 12 of 14
EXHIBIT B
LIMITED POWER OF ATTORNEY
FOR
SECTION 13 REPORTING OBLIGATIONS
Know all by these presents, that the undersigned hereby makes, constitutes and
appoints each of Robert Rosselot and Maria Gray, each acting individually, as the
undersigned’s true and lawful attorney‑in‑fact, with full power and authority as
hereinafter described on behalf of and in the name, place and stead of the undersigned
to:
(1) prepare, execute, acknowledge, deliver and file Schedules 13D and 13G (including
any amendments thereto or any related documentation) with the United States Securities
and Exchange Commission, any national securities exchanges and Franklin Resources, Inc.,
a Delaware corporation (the “Reporting Entity”), as considered necessary or advisable
under Section 13 of the Securities Exchange Act of 1934 and the rules and regulations
promulgated thereunder, as amended from time to time (the “Exchange Act”); and
(2) perform any and all other acts which in the discretion of such attorney‑in‑fact
are necessary or desirable for and on behalf of the undersigned in connection with the
foregoing.
The undersigned acknowledges that:
(1) this Limited Power of Attorney authorizes, but does not require, each such
attorney‑in‑fact to act in their discretion on information provided to such
attorney‑in‑fact without independent verification of such information;
(2) any documents prepared and/or executed by either such attorney‑in‑fact on behalf of
the undersigned pursuant to this Limited Power of Attorney will be in such form and will
contain such information and disclosure as such attorney‑in‑fact, in his or her
discretion, deems necessary or desirable;
(3) neither the Reporting Entity nor either of such attorneys‑in‑fact assumes (i) any
liability for the undersigned’s responsibility to comply with the requirements of the
Exchange Act or (ii) any liability of the undersigned for any failure to comply with such
requirements; and
(4) this Limited Power of Attorney does not relieve the undersigned from responsibility
for compliance with the undersigned’s obligations under the Exchange Act, including
without limitation the reporting requirements under Section 13 of the Exchange Act.
The undersigned hereby gives and grants each of the foregoing attorneys‑in‑fact full
power and authority to do and perform all and every act and thing whatsoever requisite,
necessary or appropriate to be done in and about the foregoing matters as fully to all
intents and purposes as the undersigned might or could do if present, hereby ratifying
all that each such attorney‑in‑fact of, for and on behalf of the undersigned, shall
lawfully do or cause to be done by virtue of this Limited Power of Attorney.
This Limited Power of Attorney shall remain in full force and effect until revoked by
the undersigned in a signed writing delivered to each such attorney‑in‑fact.
IN WITNESS WHEREOF, the undersigned has caused this Limited Power of Attorney to be
executed as of this
30th
day of
April
, 2007
/s/Charles B. Johnson
Signature
Charles B. Johnson
Print Name
CUSIP NO. 576314108 13G Page 13 of 14
LIMITED POWER OF ATTORNEY
FOR
SECTION 13 REPORTING OBLIGATIONS
Know all by these presents, that the undersigned hereby makes, constitutes and
appoints each of Robert Rosselot and Maria Gray, each acting individually, as the
undersigned’s true and lawful attorney‑in‑fact, with full power and authority as
hereinafter described on behalf of and in the name, place and stead of the undersigned
to:
(1) prepare, execute, acknowledge, deliver and file Schedules 13D and 13G (including
any amendments thereto or any related documentation) with the United States Securities
and Exchange Commission, any national securities exchanges and Franklin Resources, Inc.,
a Delaware corporation (the “Reporting Entity”), as considered necessary or advisable
under Section 13 of the Securities Exchange Act of 1934 and the rules and regulations
promulgated thereunder, as amended from time to time (the “Exchange Act”); and
(2) perform any and all other acts which in the discretion of such attorney‑in‑fact
are necessary or desirable for and on behalf of the undersigned in connection with the
foregoing.
The undersigned acknowledges that:
(1) this Limited Power of Attorney authorizes, but does not require, each such
attorney‑in‑fact to act in their discretion on information provided to such
attorney‑in‑fact without independent verification of such information;
(2) any documents prepared and/or executed by either such attorney‑in‑fact on behalf of
the undersigned pursuant to this Limited Power of Attorney will be in such form and will
contain such information and disclosure as such attorney‑in‑fact, in his or her
discretion, deems necessary or desirable;
(3) neither the Reporting Entity nor either of such attorneys‑in‑fact assumes (i) any
liability for the undersigned’s responsibility to comply with the requirements of the
Exchange Act or (ii) any liability of the undersigned for any failure to comply with such
requirements; and
(4) this Limited Power of Attorney does not relieve the undersigned from responsibility
for compliance with the undersigned’s obligations under the Exchange Act, including
without limitation the reporting requirements under Section 13 of the Exchange Act.
The undersigned hereby gives and grants each of the foregoing attorneys‑in‑fact full
power and authority to do and perform all and every act and thing whatsoever requisite,
necessary or appropriate to be done in and about the foregoing matters as fully to all
intents and purposes as the undersigned might or could do if present, hereby ratifying
all that each such attorney‑in‑fact of, for and on behalf of the undersigned, shall
lawfully do or cause to be done by virtue of this Limited Power of Attorney.
This Limited Power of Attorney shall remain in full force and effect until revoked by
the undersigned in a signed writing delivered to each such attorney‑in‑fact.
IN WITNESS WHEREOF, the undersigned has caused this Limited Power of Attorney to be
executed as of this
25th
day of
April
, 2007
/s/ Rupert H. Johnson, Jr.
Signature
Rupert H. Johnson, Jr.
Print Name
CUSIP NO. 576314108 13G Page 14 of 14
EXHIBIT C
Franklin Advisers, Inc. Item 3 Classification: 3(e)
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